Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest Ansermet 24, 1211, Geneva, Switzerland.
Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest Ansermet 24, 1211, Geneva, Switzerland.
Talanta. 2020 Aug 1;215:120894. doi: 10.1016/j.talanta.2020.120894. Epub 2020 Mar 12.
Three dimensional printed open port probe (3DP-OPP) and air displacement based liquid handler, were designed and optimized using fused deposition modeling (FDM) and stereolitography (SLA) 3D printing. The performance of the devices were investigated for the analysis of solid and liquid samples with electrospray ionization mass spectrometry (ESI-MS). Direct analysis in less than 1 min and without any sample preparation, enabled detection of pesticides (azoxtystrobin/imazalil) on fruits peel surface and illegal substances (MDMA/MDEA) in home-made pills. Conjunction of OPP in the overspill mode with a customized autosampler, equipped with disposable pipette tips, enables direct quantitative analysis of drugs of abuse in urine and plasma, with minimized carry-over and reduced matrix effect compared to flow injection analysis.
三维打印开放式端口探头（3DP-OPP）和基于空气置换的液体处理装置，使用熔融沉积建模（FDM）和立体光刻（SLA）3D 打印进行了设计和优化。这些设备的性能已通过电喷雾电离质谱（ESI-MS）分析固体和液体样品进行了研究。无需任何样品制备，直接分析时间少于 1 分钟，可在水果皮表面检测到农药（唑菌酯/咪鲜胺）和自制药丸中的非法物质（MDMA/MDEA）。将 OPP 溢出模式与配备一次性移液管吸头的定制自动进样器结合使用，可直接定量分析尿液和血浆中的滥用药物，与流动注射分析相比，可最大程度减少交叉污染并降低基质效应。
