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亚洲首例使用常温机器灌注保存延长标准供肝的初步经验

First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia.

机构信息

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).

Organ Transplant Center, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, Guangdong, China (mainland).

出版信息

Ann Transplant. 2020 Apr 21;25:e921529. doi: 10.12659/AOT.921529.

DOI:10.12659/AOT.921529
PMID:32312947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7193227/
Abstract

BACKGROUND Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. CASE REPORT From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. CONCLUSIONS NMP provides a potential tool for preservation and assessment of ECD livers in China.

摘要

背景

常温机器灌注 (NMP) 可提供在移植前评估和复苏高危供体肝脏的机会。本研究的目的是确定 NMP 在保存和评估中国扩展标准供体 (ECD) 肝脏中的效果。

病例报告

自 2018 年 9 月至 2019 年 3 月，3 家移植中心的 4 个肝移植物被定义为 ECD，并进行了 NMP，然后成功移植。在灌注过程中，记录了灌注参数，如血管流量、葡萄糖水平、乳酸清除率和胆汁生成/成分，以评估移植物的活力。所有受者在移植后 6 个月进行随访。

结论

NMP 为中国 ECD 肝脏的保存和评估提供了一种潜在的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/a8b9b83831f3/anntransplant-25-e921529-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/b04c30a43c29/anntransplant-25-e921529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/521802dcf971/anntransplant-25-e921529-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/8758d136806a/anntransplant-25-e921529-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/7d59851b4ef8/anntransplant-25-e921529-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/a8b9b83831f3/anntransplant-25-e921529-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/b04c30a43c29/anntransplant-25-e921529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/521802dcf971/anntransplant-25-e921529-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/8758d136806a/anntransplant-25-e921529-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/7d59851b4ef8/anntransplant-25-e921529-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc9/7193227/a8b9b83831f3/anntransplant-25-e921529-g005.jpg

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The impact of major extended donor criteria on graft failure and patient mortality after liver transplantation.
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