头颈部小汗腺癌：120例病例的荟萃分析。
Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases.
作者信息
Le Nguyen-Son, Janik Stefan, Liu David T, Grasl Stefan, Faisal Muhammad, Pammer Johannes, Schickinger-Fischer Bettina, Hamzavi Jafar-Sasan, Seemann Rudolf, Erovic Boban M
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.
Institute of Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.
出版信息
Head Neck. 2020 Sep;42(9):2644-2659. doi: 10.1002/hed.26178. Epub 2020 Apr 21.
BACKGROUND
The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck.
METHODS
One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta-analysis.
RESULTS
At an average follow up of 20.48 months, the 3-year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3-year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors.
CONCLUSION
Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease-free survival. Due to the high probability of recurrence, close follow-ups are strongly recommended.
背景
本研究旨在分析头颈部小汗腺癌（EPC）患者的潜在预后因素，并评估有关临床结局的治疗策略。
方法
来自90项研究的116例EPC病例和4位作者的EPC病例纳入荟萃分析。
结果
平均随访20.48个月，3年总生存率和区域复发率分别为70.3%和19.0%。未接受手术治疗的患者3年总生存率明显较差。与广泛切除相比，莫氏显微外科手术导致区域复发的发生率明显更低。溃疡病变、高有丝分裂活性和淋巴管浸润是显著的预后因素。
结论
手术切除是EPC治疗的基石，是提供无病生存最佳机会的治疗方式。由于复发概率高，强烈建议密切随访。
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