Mertin J, Meade C J, Hunt R, Sheena J
Int Arch Allergy Appl Immunol. 1977;53(5):469-73. doi: 10.1159/000231785.
Certain immuno-inhibitory effects of a polyunsaturated fatty acid, linoleic acid (C18:2), no longer occur after splenectomy of young adult CBA mice. This observation suggest that the spleen is a major intermediary in the action of C18:2 on the lymphoreticular system. Pathways of this action remain to be elucidated. Possibilities include C18:2-stimulated suppressor cell generation in the spleen, or excess biosynthesis of immuno-inhibitory prostaglandins by splenic macrophages.
多不饱和脂肪酸亚油酸（C18:2）的某些免疫抑制作用在年轻成年CBA小鼠脾切除后不再出现。这一观察结果表明，脾脏是C18:2对淋巴网状系统作用的主要中介。这种作用的途径仍有待阐明。可能性包括脾脏中C18:2刺激的抑制细胞生成，或脾巨噬细胞过量生物合成免疫抑制性前列腺素。
