Mellin W, Grundmann E
Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, FRG.
Pathol Res Pract. 1988 Dec;184(1):6-10. doi: 10.1016/S0344-0338(88)80184-5.
The stemline heterogeneity of malignant tumors is closely connected with tumor aneuploidy. Both features can be characterized by either chromosome analysis or DNA cytophotometry. DNA analysis may be performed either by single cell photometry or by flow cytometry, of which the respective advantages and drawbacks are presented. Preliminary results of flow cytometric DNA analysis in malignant neoplasms are discussed; the possibilities of multiparametric measurement for quantitative analysis of various biochemical and antigenic properties in DNA stemlines are considered.
恶性肿瘤的干系异质性与肿瘤非整倍体密切相关。这两种特征均可通过染色体分析或DNA细胞光度测定法来表征。DNA分析可通过单细胞光度测定法或流式细胞术进行，文中介绍了二者各自的优缺点。讨论了恶性肿瘤流式细胞术DNA分析的初步结果；还探讨了对DNA干系中各种生化和抗原特性进行定量分析的多参数测量可能性。
