Wang Yong-Ming, Zhang Yi-Jing, Cai Xin-Lu, Yang Han-Xue, Shan Hai-di, Cheung Eric F C, Chan Raymond C K
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, 100101, PR China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100190, PR China; Sino-Danish Center for Education and Research, Beijing, 100190, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, 100101, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
Asian J Psychiatr. 2020 Aug;52:102096. doi: 10.1016/j.ajp.2020.102096. Epub 2020 Apr 14.
Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.
以往研究发现，精神分裂症-强迫症患者、精神分裂症患者和强迫症患者存在大脑结构改变。然而，尚不清楚在具有高精神分裂症-强迫特质（SOT）、高分裂型特质（SCT）和强迫症状（OCS）的个体中是否也会出现类似的大脑变化。在本研究中，我们检查了26名高SOT个体、30名高SCT个体、25名OCS个体和30名低特质得分（LT）个体的灰质体积（GMV）和白质完整性（WMI，包括分数各向异性、平均扩散率、轴向扩散率和径向扩散率）。我们还对亚临床组中GMV、WMI、分裂型人格问卷（SPQ）得分和强迫观念及强迫行为量表修订版（OCI-R）得分进行了相关分析。我们发现，与LT组相比，SOT组右侧枕上回和左侧中央后回的GMV增加。与LT组相比，SCT组右侧中央前回和双侧楔叶的GMV增加，与其他三组相比，前放射冠的分数各向异性降低。与LT组相比，OCS组左侧颞上回的GMV增加，左侧辅助运动前区的GMV降低。这些发现突出了高SOT、高SCT和OCS个体的特定大脑变化，因此可能为这些疾病亚临床人群中发生的神经生物学变化提供新的见解。
