Constantinescu Caius M, Jacobsen Michael K, Gerke Oke, Andersen Mikkel Ø, Høilund-Carlsen Poul F
Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark.
Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark.
Diagnostics (Basel). 2020 Apr 16;10(4):226. doi: 10.3390/diagnostics10040226.
This study measures the total graft of F-sodium fluoride (NaF) uptake in non-instrumented posterolateral lumbar fusion (niPLF) patients one month after surgery and correlates it with the difference in the clinical findings between the baseline and one year after surgery. The walking distance (WLK-D), visual analog scale of back pain (VAS-B), VAS score of leg pain (VAS-L), tandem test (TAN), Oswestry Disability Index questionnaire (ODI), and European Quality of Life-5 Dimensions questionnaire (EQ-5D) were assessed before surgery and one year after. The graft NaF uptake was analyzed quantitatively with a fixed threshold algorithm resulting in the total graft uptake (SUVtotal) and partial volume corrected SUVtotal (cSUVtotal). Only 4 out of 18 patients experienced fusion; they had an insignificantly lower median total graft uptakes, i.e., 1178 SUVtotal vs. 1224 SUVtotal ( = 0.73) and 1282 cSUVtotal vs. 1231 cSUVtotal ( = 0.35), respectively. Similarly, fused patients experienced insignificantly larger pain decreases, i.e., median VAS-B 4.3 vs. 3.8 ( = 0.92) and VAS-L -6.4 vs. -4.4 ( = 0.2). We found an insignificant trend for a lower NaF uptake and less pain in fused patients. The NaF uptake did not correlate with the chronological change in the clinical parameters.
本研究测量了非器械辅助后外侧腰椎融合术（niPLF）患者术后1个月时氟化钠（NaF）摄取的总移植物情况，并将其与基线和术后1年临床结果的差异进行关联分析。术前及术后1年评估步行距离（WLK-D）、背痛视觉模拟评分（VAS-B）、腿痛VAS评分（VAS-L）、串联试验（TAN）、奥斯威斯利功能障碍指数问卷（ODI）和欧洲五维健康量表问卷（EQ-5D）。采用固定阈值算法对移植物NaF摄取进行定量分析，得出总移植物摄取量（SUVtotal）和部分容积校正SUVtotal（cSUVtotal）。18例患者中只有4例实现融合；他们的总移植物摄取中位数显著较低，即分别为1178 SUVtotal对1224 SUVtotal（P = 0.73）和1282 cSUVtotal对1231 cSUVtotal（P = 0.35）。同样，融合患者的疼痛减轻幅度也无显著差异，即VAS-B中位数4.3对3.8（P = 0.92），VAS-L -6.4对-4.4（P = 0.2）。我们发现融合患者的NaF摄取较低且疼痛较轻的趋势不显著。NaF摄取与临床参数的时间变化无关。
