用于研究分化和去分化分子机制的全生物体模型
Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation.
作者信息
Anwar Areeba, Siddiqui Ruqaiyyah, Khan Naveed Ahmed
机构信息
Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway 47500, Malaysia.
Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, University City 26666, UAE.
出版信息
Biology (Basel). 2020 Apr 17;9(4):79. doi: 10.3390/biology9040079.
Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, , as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation.
尽管治疗方法取得了进展，但癌症复发仍然是一个重大挑战。部分原因在于我们对癌症干细胞生物学及其潜在分子机制的理解不完整。分化和去分化（表型转换）现象不仅是干细胞所特有的，在其他几种生物以及与进化相关的微生物中也有观察到。在此，我们提议使用一种原始的真核单细胞生物， ，作为研究细胞分化和去分化分子机制的模型。
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