Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Department of Forensic Pathology, Medical School of Basic and Forensic Sciences Sichuan University, Chengdu, China.
Sci Rep. 2020 Apr 21;10(1):6738. doi: 10.1038/s41598-020-62609-4.
The correlation between hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains to be clarified. In this study, we explored this association in a large population in Southwest China. This was a cross-sectional study, with pooled adult health data. Multivariate logistic regression analysis, controlling for age, sex, HBV status, alanine aminotransferase, and fatty liver, was used to identify predictor(s) of MetS. Of the 96,175 participants, positive HBV was identified in 7984 (8.30%) and MetS in 12,092 (12.57%). The MetS prevalence was lower among HBV positive than negative individuals (11.64% versus 12.66%, P < 0.001). The adjusted odds (aOR) of positive HBV among individuals with MetS was 0.841 (95% confidence interval (CI), 0.771-0.916) in men and 0.834 (95% CI, 0.672-0.925) in women. Elevated triglyceride level, a component of MetS, was inversely associated with HBV status in both men and women: aOR, 0.551 (95% CI, 0.514-0.590) and 0.683 (95% CI, 0.605-0.769), respectively. Among HBV positive individuals, liver cirrhosis was more common among those with than without MetS (4.83% versus 2.93%, respectively; P = 0.002). HBsAg-seropositive are inversely associated with MetS, especially elevated triglycerides. Liver cirrhosis was more common among HBV infection patients with MetS.
乙型肝炎病毒（HBV）感染与代谢综合征（MetS）之间的关系尚不清楚。本研究在我国西南地区的一个大人群中探讨了这种相关性。这是一项横断面研究，合并了成人健康数据。采用多变量逻辑回归分析，控制年龄、性别、HBV 状态、丙氨酸氨基转移酶和脂肪肝，以确定 MetS 的预测因素。在 96175 名参与者中，有 7984 名（8.30%）HBV 阳性，12092 名（12.57%）患有 MetS。HBV 阳性者的 MetS 患病率低于 HBV 阴性者（11.64%对 12.66%，P<0.001）。在患有 MetS 的个体中，HBV 阳性的调整比值比（aOR）为男性 0.841（95%置信区间（CI），0.771-0.916），女性 0.834（95%CI，0.672-0.925）。代谢综合征的一个组成部分，甘油三酯水平升高，在男性和女性中均与 HBV 状态呈负相关：aOR，0.551（95%CI，0.514-0.590）和 0.683（95%CI，0.605-0.769）。在 HBV 阳性个体中，肝硬化在有 MetS 的个体中比没有 MetS 的个体更常见（分别为 4.83%和 2.93%；P=0.002）。HBsAg 阳性与 MetS 呈负相关，尤其是与甘油三酯升高有关。HBV 感染患者中 MetS 更常见的是肝硬化。
