Leslom Abdullah Nasser, Alrawiah Ziyad Mohammed Saeed, Al-Asmari Ahmed Mohammed Ahmed, Alqashaneen Moneer Dhafer Ali, Alahmari Abdulaziz Oudah Tami, Al-Ahmari Hamuod Oudah Bin Tami
Intern, College of Medicine, King Khalid University, Abha, Saudi Arabia.
J Family Med Prim Care. 2020 Feb 28;9(2):497-501. doi: 10.4103/jfmpc.jfmpc_1076_19. eCollection 2020 Feb.
This study was aimed to assess the prevalence of pulmonary thromboembolism in patients with nephrotic syndrome. An electronic search was conducted through nine electronic databases for selection of relevant articles reporting the prevalence of pulmonary thromboembolism in patients with nephrotic syndrome. National Institute of Health was used to assess the quality of each study. Meta-analysis was used to pool the results. Of total 2267 reports screened, we finally included 11 studies including five retrospective cohorts, four prospective cohorts, and two case series studies. Out of these, ten articles were eligible for meta-analysis. The overall prevalence was 7.93% with 95% CI of 4.27 to 14.73. However, a significant heterogeneity ( < 0.001) was observed with I2= 96% and τ2= 0.899. Moreover, Egger's regression test showed a significant risk of bias ( = 0.006). Patients with nephrotic syndrome are prone to pulmonary embolism, therefore early management is critical to decreasing mortality burden.
本研究旨在评估肾病综合征患者肺血栓栓塞症的患病率。通过九个电子数据库进行电子检索，以筛选报告肾病综合征患者肺血栓栓塞症患病率的相关文章。使用美国国立医学图书馆（NLM）来评估每项研究的质量。采用荟萃分析来汇总结果。在总共筛选的2267篇报告中，我们最终纳入了11项研究，包括五项回顾性队列研究、四项前瞻性队列研究和两项病例系列研究。其中，十篇文章符合荟萃分析的条件。总体患病率为7.93%，95%置信区间为4.27至14.73。然而，观察到显著的异质性（<0.001），I2 = 96%，τ2 = 0.899。此外，Egger回归检验显示存在显著的偏倚风险（= 0.006）。肾病综合征患者易发生肺栓塞，因此早期管理对于减轻死亡负担至关重要。
