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乙肝抗原血症、肾病综合征与肺栓塞:一系列不幸事件——病例报告

Hepatitis B Antigenaemia, Nephrotic Syndrome and Pulmonary Embolism A Series of Unfortunate Events: A Case Report.

作者信息

Malik Muhammad Hassaan, Faheem Muhammad Shaheer Bin, Shaheryar Khawaja, Iqbal Javed, Nasar Syed Aun Bin

机构信息

Department of Internal Medicine Shifa International Hospital Islamabad Pakistan.

Department of Internal Medicine Karachi Institute of Medical Sciences, KIMS Karachi Pakistan.

出版信息

Respirol Case Rep. 2025 Mar 10;13(3):e70145. doi: 10.1002/rcr2.70145. eCollection 2025 Mar.

DOI:10.1002/rcr2.70145
PMID:40065795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11893189/
Abstract

Hepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability. This hypercoagulable state may lead to a life-threatening complication of nephrotic syndrome: thromboembolism. This case report presents a rare medical case where a patient with chronic HBV develops nephrotic syndrome and subsequent pulmonary embolism. The co-occurrence of these diseases in a single patient highlights the importance of their intricate pathology. By examining this unique case, we aim to highlight the diagnostic and therapeutic challenges in such clinical presentations, providing valuable insight for professionals dealing with similar cases.

摘要

乙型肝炎是一个主要的健康问题。它主要影响肝脏,但也可引起全身并发症,如抗原血症和肾病综合征。肾病综合征会导致蛋白尿、低白蛋白血症、水肿、高脂血症和高凝状态。这种高凝状态可能导致肾病综合征的一种危及生命的并发症:血栓栓塞。本病例报告展示了一个罕见的医学案例,一名慢性乙肝患者发展为肾病综合征并随后发生肺栓塞。这些疾病在同一患者身上的共同出现凸显了其复杂病理的重要性。通过研究这个独特的病例,我们旨在突出此类临床表现中的诊断和治疗挑战,为处理类似病例的专业人员提供有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a9/11893189/1f52b55164d6/RCR2-13-e70145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a9/11893189/1f52b55164d6/RCR2-13-e70145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a9/11893189/1f52b55164d6/RCR2-13-e70145-g002.jpg

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本文引用的文献

1
Thromboembolism in nephrotic syndrome: controversies and uncertainties.肾病综合征中的血栓栓塞:争议与不确定性。
Res Pract Thromb Haemost. 2023 Aug 9;7(6):102162. doi: 10.1016/j.rpth.2023.102162. eCollection 2023 Aug.
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Prevalence of pulmonary thromboembolism in nephrotic syndrome patients: A systematic review and meta-analysis.肾病综合征患者肺血栓栓塞症的患病率:一项系统评价和荟萃分析。
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Membranous nephropathy related to hepatitis B virus in adults.成人乙型肝炎病毒相关性膜性肾病
N Engl J Med. 1991 May 23;324(21):1457-63. doi: 10.1056/NEJM199105233242103.