Leslom Abdullah Nasser, Alqahtani Fahad Juwayid, Hanash Abdulbari Ahmed Saeed, Alsubaie Abdullah Abdulhadi, Alamri Mohammed Saeed
Intern, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Medical Student, College of Medicine, King Khalid University, Abha, Saudi Arabia.
J Family Med Prim Care. 2020 Feb 28;9(2):898-903. doi: 10.4103/jfmpc.jfmpc_993_19. eCollection 2020 Feb.
Colorectal carcinoma is the most evident carcinoma in the elderly. Despite its high incidence and mortality rate, there is insufficient research about the best treatment options for colorectal carcinoma.
This study was designed to assess the best treatment modality for colorectal carcinoma in elderly Saudi patients.
We conducted a retrospective analysis of medical records at the Princess Norah Oncology Center (PNOC), King Abdulaziz Medical City, Jeddah, Saudi Arabia. We included patients treated at PNOC between 2010 and 2015. Only patients aged above 70 years with advanced colon were included in the study.
The cohort included 57 patients with an average age of 76.51 with 27 alive patients and 30 dead patients. Nonmucinous adenocarcinoma had significant higher mortality ( = 20). Most patients received surgical treatment which was associated with less risk for mortality; however, it was nonsignificant. Surgery was followed by first-line treatment which had a mortality rate of 50%. The least treatment associated with mortality was local liver treatment ( = 0). Survival analysis found that only treatment with significant higher survival was shift to next line of treatment (at least once) [HR = 0.06, 95% CI (0.00, 0.79), value = 0.03]. Other treatments were not associated with significant mortality reduction. First-line treatment was associated with higher mortality risk; nevertheless, it was nonsignificant.
Local radiotherapy and local liver ablation had the least mortality rate. However, in multivariate Cox regression analysis, we found that shift to next line of treatment was associated with the significant high survival rate.
结直肠癌是老年人中最常见的癌症。尽管其发病率和死亡率很高，但关于结直肠癌最佳治疗方案的研究仍不充分。
本研究旨在评估沙特老年患者结直肠癌的最佳治疗方式。
我们对沙特阿拉伯吉达阿卜杜勒阿齐兹国王医疗城诺拉公主肿瘤中心（PNOC）的病历进行了回顾性分析。纳入了2010年至2015年在PNOC接受治疗的患者。本研究仅纳入年龄在70岁以上的晚期结肠癌患者。
该队列包括57例患者，平均年龄为76.51岁，其中27例存活，30例死亡。非黏液性腺癌的死亡率显著更高（=20）。大多数患者接受了手术治疗，手术相关的死亡风险较低；然而，差异无统计学意义。手术后进行一线治疗，死亡率为50%。与死亡率相关最少的治疗是局部肝脏治疗（=0）。生存分析发现，只有显著提高生存率的治疗是转至下一线治疗（至少一次）[风险比=0.06，95%置信区间（0.00，0.79），P值=0.03]。其他治疗与死亡率的显著降低无关。一线治疗与较高的死亡风险相关；然而，差异无统计学意义。
局部放疗和局部肝脏消融的死亡率最低。然而，在多变量Cox回归分析中，我们发现转至下一线治疗与显著较高的生存率相关。
