血栓闭塞性脉管炎的临床谱在过去 40 年中发生了变化吗？

Did the Clinical Spectrum of Thromboangiitis Obliterans Change in the Past 40 Years?

机构信息

Department of Internal Medicine, Hôpital HURIEZ, CHRU Lille, France.

Department of Internal Medicine and Clinical Immunology, Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, des Maladies Auto-Inflammatoires et de l'Amylose, Paris, France.

出版信息

Angiology. 2020 Aug;71(7):621-625. doi: 10.1177/0003319720920163. Epub 2020 Apr 22.

DOI:10.1177/0003319720920163

PMID:32319306

Abstract

Thromboangiitis obliterans (TAO) is an inflammatory disease that usually affects small and medium-sized arteries in the upper and lower limbs of young smokers. Previous studies showed that the spectrum TAO has changed in the 80s: the male-to-female ratio decreased, older patients were diagnosed, and upper limb involvement was more common. The aim of our study was to assess the changing clinical spectrum of TAO in France during the past 40 years. All consecutive patients fulfilling TAO's criteria between January 1967 and January 2016 were retrospectively included in 3 departments of internal medicine. We compared TAO features in patients diagnosed before and after 2002; 141 (77.5%) men and 41 (22.5%) women were included. Patients diagnosed after 2002 were older (37 [31-39] vs 34 [29-35] years = .03), had a more frequent isolated upper limb involvement (34.3% vs 7.8% = .001), and less frequent isolated lower limb involvement (55.7% vs 74.5%, < .001). The clinical spectrum of TAO has changed in France since the beginning of the 21st century.

摘要

血栓闭塞性脉管炎（TAO）是一种炎症性疾病，通常影响年轻吸烟者上肢和下肢的小动脉和中等动脉。先前的研究表明，80 年代以来 TAO 的谱已发生变化：男女比例下降，诊断出更年长的患者，上肢受累更为常见。我们的研究旨在评估过去 40 年来法国 TAO 的临床谱变化。1967 年 1 月至 2016 年 1 月期间，3 个内科部门连续纳入符合 TAO 标准的所有患者。我们比较了 2002 年前和 2002 年后诊断的 TAO 特征；纳入了 141 名男性（77.5%）和 41 名女性（22.5%）。2002 年后诊断的患者年龄更大（37 [31-39] 岁 vs 34 [29-35] 岁，.03），更常发生孤立的上肢受累（34.3% vs 7.8%，.001），孤立的下肢受累更少（55.7% vs 74.5%，.001）。自 21 世纪初以来，法国 TAO 的临床谱发生了变化。