Centro Hospitalar do Médio Ave EPE, Vila Nova de Famalicão, Portugal
Centro Hospitalar Universitário do Porto EPE Centro Materno-Infantil do Norte Dr Albino Aroso, Porto, Portugal.
BMJ Case Rep. 2023 Dec 18;16(12):e252306. doi: 10.1136/bcr-2022-252306.
Buerger's disease (BD), also known as thromboangiitis obliterans, is a non-atherosclerotic inflammatory disorder of unknown aetiology that affects small-sized and medium-sized vessels of the extremities. It is usually observed in middle-aged adults, especially those who smoke or use tobacco products. This condition is more frequently observed in men, although recent findings indicate an increasing prevalence among women, potentially due to increased cigarette use. The association between pregnancy and BD is rare, with only a few published cases. Previous reports have indicated that BD may worsen during gestation due to the characteristic hypercoagulable state of pregnancy. In addition, it seems to be associated with intrauterine growth restriction secondary to infarction of placental vessels. Careful obstetric management of maternal and fetal status is mandatory in pregnancies complicated with BD. We report a successful case of a pregnancy in a patient with BD treated with low-molecular-weight heparin.
伯格氏病（BD），又称血栓闭塞性脉管炎，是一种病因不明的非粥样硬化性炎症性疾病，影响四肢的小血管和中等大小的血管。它通常发生在中年成年人中，尤其是那些吸烟或使用烟草制品的人。这种情况在男性中更为常见，尽管最近的研究结果表明女性中的发病率在增加，这可能是由于吸烟增加所致。妊娠与 BD 之间的关联很少见，只有少数已发表的病例。以前的报告表明，由于妊娠的特征性高凝状态，BD 在妊娠期间可能会恶化。此外，它似乎与胎盘血管梗死引起的宫内生长受限有关。对于合并 BD 的妊娠，必须对母婴状况进行仔细的产科管理。我们报告了一例使用低分子量肝素治疗的 BD 患者成功妊娠的病例。
