Department of Anesthesia, The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Department of Anesthesia, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Acta Anaesthesiol Scand. 2020 Sep;64(8):1187-1193. doi: 10.1111/aas.13611. Epub 2020 May 14.
Despite an increase in the rates of epidural labor analgesia, continuation of epidural labor analgesia in the second stage of labor (CEADSSOL) was interrupted by care providers due to fears of increased risk of operative delivery and adverse neonatal outcomes. Therefore, we evaluated the effect of CEADSSOL and the newer American College of Obstetricians and Gynecologists (ACOG) definition of arrest of labor on the length of secondary stage of labor, newborn outcomes, and mode of delivery.
This is a retrospective cohort study. Data collection began during March 2014 and ended in May 2015, 1 year after implementation of both interventions. The primary outcome was the length of secondary stage of labor, mode of delivery and neonatal outcome (Apgar < 7, at 5 minutes). The implementation of continuing epidural analgesia during the second stage of labor was performed with 0.08%-0.15% ropivacaine and 0.1-0.2 µg/mL sufentanil.
There were a total 10 414 deliveries during the study period. The length of the second stage of labor has no significant differences among groups. The cesarean delivery rate decreased 4.1% (36% vs 40.1%, P = .0038). Moreover, no significant difference was found in neonatal Apgar scores less than 7 at 5 minutes between two phases. Maternal outcomes remained unchanged. Post-intervention neonatal parameters including NICU admissions (P < .001), incidences of antibiotics usage (P < .0001), intubation (P = .0003), and 7 days mortality (P = .0020) were remarkably reduced compared to pre-interventions.
The important finding of this study was the improvement in neonatal outcomes by implementing two simultaneous interventions without a cost of increased operative delivery.
尽管硬膜外分娩镇痛的比例有所增加,但由于担心剖宫产率和新生儿不良结局的风险增加,医护人员中断了第二产程的硬膜外分娩镇痛(CEADSSOL)。因此,我们评估了 CEADSSOL 和较新的美国妇产科医师学会(ACOG)对产程停滞的定义对第二产程时长、新生儿结局和分娩方式的影响。
这是一项回顾性队列研究。数据收集始于 2014 年 3 月,止于 2015 年 5 月,即这两项干预措施实施 1 年后。主要结局是第二产程时长、分娩方式和新生儿结局(Apgar<7,5 分钟时)。第二产程持续硬膜外镇痛采用 0.08%-0.15%罗哌卡因和 0.1-0.2μg/ml舒芬太尼实施。
研究期间共有 10414 例分娩。各组间第二产程时长无显著差异。剖宫产率降低了 4.1%(36%比 40.1%,P=0.0038)。此外,两个阶段 5 分钟时新生儿 Apgar 评分<7 分的比例无显著差异。产妇结局保持不变。与干预前相比,干预后新生儿参数(包括新生儿重症监护病房(NICU)入院率(P<0.001)、抗生素使用率(P<0.0001)、插管率(P=0.0003)和 7 天死亡率(P=0.0020))显著降低。
本研究的重要发现是,通过实施两项同时干预措施,在不增加剖宫产率的情况下改善了新生儿结局。