口腔舌鳞癌：具有独特流行病学特征的疾病。
Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Head Neck. 2020 Sep;42(9):2316-2320. doi: 10.1002/hed.26177. Epub 2020 Apr 22.
BACKGROUND
Oral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity. Our goal was to investigate the epidemiological features of OSCC with relation to age and subsite.
METHODS
Retrospective review of all patients treated for OSCC in a tertiary care center between 2000 and 2018.
RESULTS
A total of 360 patients were included. Five age groups were defined: 0 to 30, 31 to 45, 46 to 60, 61 to 75, and 76+. In the 0 to 30 and 31 to 45 groups, 94.6% of tumors originated in the oral tongue compared to 87%, 66%, and 61% in the 46 to 60, 61 to 75, and 76+ groups, respectively (P < .001). A higher proportion of oral tongue SCC (OTSCC) was found in nonsmokers (76% vs 62%, P = .02). In nonsmokers aged 0 to 60, 97.9% had OTSCC compared to 67.5% in the 61+ groups (P < .001).
CONCLUSIONS
OSCC in young nonsmokers originates primarily in the tongue. The etiology of OTSCC in young patients may be different than other OSCC subsites and not related to smoking.
背景
口腔鳞状细胞癌（OSCC）发生在口腔内的不同部位。我们的目标是研究与年龄和部位相关的 OSCC 的流行病学特征。
方法
回顾性分析 2000 年至 2018 年在一家三级保健中心治疗的所有 OSCC 患者。
结果
共纳入 360 例患者。定义了 5 个年龄组：0 至 30 岁、31 至 45 岁、46 至 60 岁、61 至 75 岁和 76+岁。在 0 至 30 岁和 31 至 45 岁组中，94.6%的肿瘤起源于口腔舌部，而在 46 至 60 岁、61 至 75 岁和 76+岁组中，这一比例分别为 87%、66%和 61%（P < .001）。非吸烟者中口腔舌部 SCC（OTSCC）的比例更高（76%比 62%，P =.02）。在年龄 0 至 60 岁的非吸烟者中，97.9%患有 OTSCC，而在 61+岁组中，这一比例为 67.5%（P < .001）。
结论
年轻非吸烟者的 OSCC 主要起源于舌部。年轻患者 OTSCC 的病因可能与其他 OSCC 部位不同，与吸烟无关。
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