School of Dentistry, China Medical University, Taichung, Taiwan.
Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Sci Rep. 2021 Jul 29;11(1):15446. doi: 10.1038/s41598-021-95007-5.
The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different anatomical subsites in the Taiwanese population. We retrospectively analyzed data for 3010 patients with OSCC treated at the Changhua Christian Hospital. Subsequently, we compared clinical and pathological features of OSCC in different subsites. Pathological T4 stage OSCCs occurred in the alveolar ridge and retromolar trigone in 56.4% and 43.7% of cases, respectively. More than 25% of patients with tongue OSCC and 23.4% of those with retromolar OSCC had lymph node metastasis. The prognosis was worst for hard palate OSCC (hazard ratio 1.848; p < 0.001) and alveolar ridge OSCC (hazard ratio 1.220; p = 0.017). Retromolar OSCC recurred most often and tongue OSCC second most often. The risk for cancer-related mortality was highest for hard palate OSCC, followed by alveolar ridge and retromolar OSCC. We found distinct differences in survival among the different subsites of OSCC. Our findings may also help prompt future investigations of OSCC in different subsites in Taiwanese patients.
口腔鳞状细胞癌（OSCC）在南亚的发病率特别高。根据国家综合癌症网络的说法，OSCC 可以发生在几个亚部位。我们研究了台湾人群中不同解剖亚部位 OSCC 的生存率和临床病理特征。我们回顾性分析了在彰化基督教医院接受治疗的 3010 例 OSCC 患者的数据。随后，我们比较了不同亚部位 OSCC 的临床和病理特征。病理 T4 期 OSCC 在牙槽嵴和磨牙后三角的发生率分别为 56.4%和 43.7%。超过 25%的舌 OSCC 患者和 23.4%的磨牙后 OSCC 患者发生淋巴结转移。硬腭 OSCC 的预后最差（风险比 1.848；p<0.001）和牙槽嵴 OSCC（风险比 1.220；p=0.017）。磨牙后 OSCC 复发最常见，其次是舌 OSCC。硬腭 OSCC 的癌症相关死亡率风险最高，其次是牙槽嵴和磨牙后 OSCC。我们发现不同部位 OSCC 的生存率存在明显差异。我们的研究结果也可能有助于未来对台湾患者不同亚部位 OSCC 的研究。
