Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal; Centro de Estudos do Ambiente e do Mar (CESAM), Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Environ Toxicol Pharmacol. 2020 Aug;78:103394. doi: 10.1016/j.etap.2020.103394. Epub 2020 Apr 13.
With the increasing awareness about the contamination of the aquatic environment by pharmaceuticals, there is a growing need to study their adverse effects on aquatic organisms. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), whose wide use contributes for its presence in freshwater ecosystems, increasing the probability of causing deleterious changes in aquatic biota. This study evaluated possible oxidative stress effects in Danio rerio embryos and larvae when exposed to a range of ecologically relevant concentrations of diclofenac. It was possible to conclude that diclofenac caused a scenario of oxidative stress, since all tested toxicological parameters were responsive to the drug. In general, diclofenac caused not only significant anti-oxidant adaptive responses for most levels of exposure, but also peroxidative damage. This work evidenced the responsiveness of D. rerio towards diclofenac in environmentally relevant concentrations, which shows that these organisms might face a scenario of oxidative stress in their natural habitat.
随着人们对水环境中药物污染的认识不断提高，越来越需要研究它们对水生生物的不良影响。双氯芬酸是一种非甾体抗炎药（NSAID），由于其广泛应用，导致其在淡水生态系统中存在，增加了对水生生物群造成有害变化的可能性。本研究评估了暴露于一系列生态相关浓度的双氯芬酸时，斑马鱼胚胎和幼虫中可能存在的氧化应激影响。可以得出结论，双氯芬酸引起了氧化应激的情况，因为所有测试的毒理学参数都对药物有反应。总的来说，双氯芬酸不仅对大多数暴露水平引起了显著的抗氧化适应性反应，而且还引起了过氧化损伤。这项工作证明了斑马鱼对环境相关浓度的双氯芬酸的反应性，这表明这些生物在其自然栖息地可能面临氧化应激的情况。
