Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Clinical Department for Anesthesia, Intensive Care and Pain Management, Clinical Centre of Vojvodina, Novi Sad, Serbia.
J Chemother. 2020 Oct;32(6):294-303. doi: 10.1080/1120009X.2020.1755588. Epub 2020 Apr 23.
A surveillance study was performed in an intensive care unit in the largest tertiary health care center in Vojvodina, Serbia from 2014 to 2018. Antibiotic prescription data were collated in the WHO anatomical therapeutic chemical (ATC)/defined daily dose (DDD) format, while antibiotic resistance was expressed as incidence density adjusted for total inpatient-days. Individual trends were determined by linear regression, while possible associations between antibiotic prescription and resistance were evaluated using cross-correlation analysis. An overall decrease in antibiotic utilization was observed. The prescription rates of piperacillin-tazobactam increased significantly, while consumption of 3rd and 4th generation cephalosporins and fluoroquinolones decreased. There were rising incidence densities of doripenem resistant spp., piperacillin-tazobactam resistant and carbapenem and colistin resistant These results can serve as a basis for the development of antimicrobial stewardship strategies in the current setting.
一项监测研究在塞尔维亚伏伊伏丁那最大的三级保健中心的重症监护病房进行，时间为 2014 年至 2018 年。抗生素处方数据按照世界卫生组织（WHO）解剖治疗化学（ATC）/限定日剂量（DDD）格式进行整理，而抗生素耐药性则以总住院日校正的发生率密度表示。通过线性回归确定个体趋势，同时使用交叉相关分析评估抗生素处方与耐药性之间的可能关联。观察到抗生素使用总体减少。哌拉西林他唑巴坦的处方率显著增加，而第三代和第四代头孢菌素和氟喹诺酮类药物的消耗量减少。多利培南耐药铜绿假单胞菌、哌拉西林他唑巴坦耐药鲍曼不动杆菌和碳青霉烯类和黏菌素耐药肠杆菌科细菌的发生率密度上升。这些结果可以作为当前环境下制定抗菌药物管理策略的基础。
