血管水平分析分数血流储备和无波间期比不匹配 - AJIP 注册研究的新视角
Per-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance - Insights From the AJIP Registry.
机构信息
Cardiovascular Science, Imperial College London.
Department of Cardiovascular Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital.
出版信息
Circ J. 2020 May 25;84(6):1034-1038. doi: 10.1253/circj.CJ-19-0785. Epub 2020 Apr 22.
BACKGROUND
The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified.
METHODS AND RESULTS
Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR-/iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR- (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17).
CONCLUSIONS
The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.
背景
疾病的生理模式对血流储备分数（FFR）和瞬时无波比值（iFR）之间不匹配的血管水平影响尚不清楚。
方法和结果
利用 AJIP 注册研究，对存在 FFR/iFR 不匹配的血管（133/671 [19.8%]）进行分析。在左前降支（LAD）中，压力导丝回撤评估的弥漫性病变与 FFR-/iFR+相关（83.3% [40/48]），而局灶性病变与 FFR+/iFR-相关（57.4% [31/54]），差异有统计学意义（P<0.0001）。在非左前降支中，差异无统计学意义（P=0.17）。
结论
在 LAD 中，疾病生理模式对 FFR/iFR 不匹配的影响更为显著。
Zotero 插件