Cardiovascular Science, Imperial College London.
Department of Cardiovascular Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital.
Circ J. 2020 May 25;84(6):1034-1038. doi: 10.1253/circj.CJ-19-0785. Epub 2020 Apr 22.
The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified.
Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR-/iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR- (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17).
The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.
疾病的生理模式对血流储备分数（FFR）和瞬时无波比值（iFR）之间不匹配的血管水平影响尚不清楚。
利用 AJIP 注册研究，对存在 FFR/iFR 不匹配的血管（133/671 [19.8%]）进行分析。在左前降支（LAD）中，压力导丝回撤评估的弥漫性病变与 FFR-/iFR+相关（83.3% [40/48]），而局灶性病变与 FFR+/iFR-相关（57.4% [31/54]），差异有统计学意义（P<0.0001）。在非左前降支中，差异无统计学意义（P=0.17）。
在 LAD 中，疾病生理模式对 FFR/iFR 不匹配的影响更为显著。
