散光成分和内部补偿的危险因素：南京眼研究。
Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study.
机构信息
Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 101 Longmian Street, 211166, Nanjing, China.
出版信息
Eye (Lond). 2021 Feb;35(2):499-507. doi: 10.1038/s41433-020-0881-5. Epub 2020 Apr 22.
PURPOSE
To determine the risk factors for total astigmatism (TA), anterior corneal astigmatism (ACA), and internal compensation in Chinese preschool children.
METHODS
In the population-based Nanjing Eye Study, children were measured for noncycloplegic refractive error and for biometric parameters. Data from questionnaires and measures from right eyes were analyzed for determining risk factors for TA, ACA, and internal compensation from multivariate logistic regression models.
RESULTS
Of 1327 children (66.8 ± 3.4 months, 53.2% male), older age of the child (OR = 0.95 for per month increase; P = 0.03), older paternal age at child birth (OR = 1.04 for per year increase; P = 0.03), paternal astigmatism (OR = 1.89; P = 0.003), maternal astigmatism (OR = 1.73, P = 0.008), and second-hand smoke exposure during pregnancy (OR = 1.64; P = 0.03) were associated with higher risk of TA, while partial breastfeeding (OR = 0.49, P = 0.006) or formula feeding (OR = 0.46, P = 0.003) were associated with lower risk of TA. Larger ratio of axial length to corneal radius (OR = 16.16 for per unit increase; P = 0.001), maternal working during pregnancy (OR = 1.27; P = 0.04), and cesarean delivery (OR = 1.68, P = 0.04) were associated with higher risk of ACA, while formula feeding was associated with lower risk of ACA (OR = 0.57, P = 0.01). Paternal astigmatism (OR = 0.50, P = 0.01) and assisted reproduction (OR = 0.56, P = 0.03) were associated with lower risk of horizontal or vertical internal compensation. More outdoor activity time (OR = 1.15 for per hour increase, P = 0.01) was associated with higher risk of oblique internal compensation while more nighttime sleep on weekends (OR = 0.83 for per hour increase, P = 0.01) was associated with lower risk of oblique internal compensation.
CONCLUSIONS
Our study confirmed some previously reported risk factors and identified some novel risk factors for astigmatism including formula feeding for lower risk of both ACA and TA, and older paternal age at child birth for higher risk of TA.
目的
确定中国学龄前儿童总散光（TA）、前角膜散光（ACA）和内部补偿的危险因素。
方法
在基于人群的南京眼科研究中，对儿童进行非睫状肌麻痹屈光不正和生物测量参数测量。对右眼的问卷调查数据和测量数据进行分析，采用多元逻辑回归模型确定 TA、ACA 和内部补偿的危险因素。
结果
在 1327 名儿童（66.8±3.4 个月，53.2%为男性）中，儿童年龄较大（每月增加 0.95；P=0.03）、父亲在孩子出生时年龄较大（每年增加 1.04；P=0.03）、父亲散光（OR=1.89；P=0.003）、母亲散光（OR=1.73，P=0.008）和怀孕期间接触二手烟（OR=1.64；P=0.03）与 TA 风险增加相关，而部分母乳喂养（OR=0.49，P=0.006）或配方奶喂养（OR=0.46，P=0.003）与 TA 风险降低相关。眼轴与角膜半径比（每单位增加 16.16；P=0.001）、母亲在怀孕期间工作（OR=1.27；P=0.04）和剖宫产（OR=1.68，P=0.04）与 ACA 风险增加相关，而配方奶喂养与 ACA 风险降低相关（OR=0.57，P=0.01）。父亲散光（OR=0.50，P=0.01）和辅助生殖（OR=0.56，P=0.03）与水平或垂直内部补偿的风险降低相关。更多的户外活动时间（每小时增加 1.15；P=0.01）与斜向内部补偿的风险增加相关，而周末夜间睡眠时间增加（每小时增加 0.83；P=0.01）与斜向内部补偿的风险降低相关。
结论
本研究证实了一些先前报道的危险因素，并确定了一些新的散光危险因素，包括配方奶喂养可降低 ACA 和 TA 的风险，以及父亲在孩子出生时年龄较大与 TA 风险增加有关。
Zotero 插件