Rovini D, Pellegris G, Cascinelli N, Cantoni L, Vaglini M, Placucci M, Santinami M, Belli F, Illeni M T
Divisione di Chirurgia Oncologica C, Istituto Nazionale per lo Studio ela Cura dei Tumori, Milano, Italia.
Tumori. 1988 Dec 31;74(6):657-64. doi: 10.1177/030089168807400607.
One hundred and twenty-four subjects belonging to 25 families, 51 with familial malignant melanoma (FMM), and 186 subjects belonging to 41 families, 41 with sporadic malignant melanoma, were typed for the HLA A, B, C and DR loci of the HLA system. There was the same statistically significant difference in the frequency of the haplotype A9, B35, Cw4 between each group of patients and the respective healthy relatives (p = 0.01, p = 0.01 and p = 4 x 10(-3), respectively). Moreover, the higher frequency of the haplotype A9, B35, Cw4 in the healthy members of the FMM families (42.46%) compared with the healthy members of the SMM families (23.44%) indicates that in the latter group other individuals are at risk for the disease. Furthermore, the different frequency of haplotypes B5, DR5 and B5, Cw1 suggest that differences exist between the two groups of healthy relatives. These observations confirm that the HLA region is involved in the etiology of malignant melanoma.
对25个家族中的124名受试者（其中51名患有家族性恶性黑色素瘤（FMM））以及41个家族中的186名受试者（其中41名患有散发性恶性黑色素瘤）进行了HLA系统的HLA A、B、C和DR位点分型。每组患者与其各自的健康亲属之间，单倍型A9、B35、Cw4的频率存在相同的统计学显著差异（分别为p = 0.01、p = 0.01和p = 4×10⁻³）。此外，FMM家族健康成员中A9、B35、Cw4单倍型的频率（42.46%）高于SMM家族健康成员（23.44%），这表明后一组中的其他个体也有患该病的风险。此外，单倍型B5、DR5和B5、Cw1的频率差异表明两组健康亲属之间存在差异。这些观察结果证实HLA区域参与了恶性黑色素瘤的病因学。
