Brückner Vanessa, Fiebiger Ulrike, Ignatius Ralf, Friesen Johannes, Eisenblätter Martin, Höck Marlies, Alter Thomas, Bereswill Stefan, Gölz Greta, Heimesaat Markus M
1Institute of Food Safety and Food Hygiene, Freie Universität Berlin, Berlin, Germany.
2Institute of Microbiology, Infectious Diseases and Immunology, Charité- University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Gut Pathog. 2020 Apr 15;12:21. doi: 10.1186/s13099-020-00360-x. eCollection 2020.
species, particularly , but also constitute emerging pathogens causing gastroenteritis in humans. However, isolation of may often fail during routine diagnostic procedures due to the lack of standard protocols. Furthermore, defined breakpoints for the interpretation of antimicrobial susceptibilities of are missing. Hence, reliable epidemiological data of human infections are scarce and lacking for Germany. We therefore performed a 13-month prospective prevalence study in German patients.
A total of 4636 human stool samples was included and spp. were identified from 0.85% of specimens in 3884 outpatients and from 0.40% of specimens in 752 hospitalized patients. Overall, was the most prevalent species (n = 24; 67%), followed by (n = 10; 28%) and (n = 2; 6%). Whereas and were identified in outpatients, only could be isolated from samples of hospitalized patients. Antimicrobial susceptibility testing of isolates revealed high susceptibilities to ciprofloxacin, whereas bimodal distributions of MICs were observed for azithromycin and ampicillin.
In summary, including , and could be isolated in 0.85% of German outpatients and ciprofloxacin rather than other antibiotics might be appropriate for antibiotic treatment of infections. Further epidemiological studies are needed, however, to provide a sufficient risk assessment of infections in humans.
某些物种，特别是[具体物种1]，但也包括[具体物种2]，构成了导致人类肠胃炎的新兴病原体。然而，由于缺乏标准方案，在常规诊断程序中分离[目标病原体]往往会失败。此外，对于[目标病原体]抗菌药敏性解释的明确断点也缺失。因此，德国缺乏关于人类[目标病原体]感染的可靠流行病学数据。我们因此对德国患者进行了一项为期13个月的前瞻性[目标病原体]患病率研究。
共纳入4636份人类粪便样本，在3884名门诊患者的0.85%样本和752名住院患者的0.40%样本中鉴定出[目标病原体]。总体而言，[最常见物种]是最普遍的物种（n = 24；67%），其次是[次常见物种]（n = 10；28%）和[又一次常见物种]（n = 2；6%）。虽然[某些物种]在门诊患者中被鉴定出来，但仅[特定物种]可从住院患者样本中分离出来。对[目标病原体]分离株的抗菌药敏试验显示对环丙沙星高度敏感，而阿奇霉素和氨苄西林的最低抑菌浓度（MIC）呈双峰分布。
总之，包括[具体物种1]、[具体物种2]和[具体物种3]在内的[目标病原体]可在0.85%的德国门诊患者中分离出来，环丙沙星而非其他抗生素可能适合用于[目标病原体]感染的抗生素治疗。然而，需要进一步的流行病学研究来对人类[目标病原体]感染进行充分的风险评估。
