Yang C, Heston W D, Gulati S, Fair W R
Department of Surgery and Memorial Sloan-Kettering Cancer Center, New York, NY.
Urol Res. 1988;16(6):427-9. doi: 10.1007/BF00280023.
The effect of High energy shock waves (HESW) on the viability and proliferation of normal human bone marrow cells was evaluated. A dose dependent increase in cytotoxicity with an increase in the number of HESW was demonstrated. In general 700 HESW immediately reduced the cell viability of bone marrow cells by 50%. The CFU-GM assay provides a method to evaluate the effect of HESW on the proliferative capacity of bone marrow. Following HESW treatment the colony forming ability of trypan blue excluding cells also felt in a dose dependent fashion, but some variation in sensitivity was noted. By comparing the sensitivity of various cells, the cells of normal human bone marrow were felt to be less sensitive to HESW effects than those of other tissue cultured cells or malignant cell lines.
评估了高能冲击波（HESW）对正常人骨髓细胞活力和增殖的影响。结果表明，随着HESW次数的增加，细胞毒性呈剂量依赖性增加。一般来说，700次HESW可使骨髓细胞的活力立即降低50%。CFU-GM检测提供了一种评估HESW对骨髓增殖能力影响的方法。HESW处理后，台盼蓝拒染细胞的集落形成能力也呈剂量依赖性下降，但观察到敏感性存在一些差异。通过比较各种细胞的敏感性，发现正常人骨髓细胞对HESW作用的敏感性低于其他组织培养细胞或恶性细胞系。
