Korovaitseva G I, Gabaeva M V, Golimbet V E
Mental Health Research Center, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):48-52. doi: 10.17116/jnevro202012003148.
To study the association of the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene with the risk of schizophrenia in a large sample, including schizophrenic patients and mentally healthy people, and to investigate the relationship of this polymorphism with the severity of schizophrenia symptoms and genotype-environment interaction effects on these symptoms.
The sample for genotyping consisted of 1357 patients with schizophrenia and schizophrenia spectrum disorders and 711 people of the control group. The severity of symptoms was assessed with the PANSS. Obstetrical complications and a traumatic brain injury in medical history were studied as environmental factors.
No association was found between C677T polymorphism and schizophrenia. There was no genotype effect on the severity of symptoms on the PANSS subscales. The effect of genotype-environment interactions on the severity of schizophrenia symptoms was not detected. The results do not confirm the data of a number of studies on the relationship of C677T polymorphism with schizophrenia symptoms.
在一个包含精神分裂症患者和心理健康人群的大样本中，研究亚甲基四氢叶酸还原酶（MTHFR）基因的C677T多态性与精神分裂症风险之间的关联，并探讨这种多态性与精神分裂症症状严重程度的关系以及基因型-环境相互作用对这些症状的影响。
基因分型样本包括1357例精神分裂症和精神分裂症谱系障碍患者以及711例对照组人群。使用阳性和阴性症状量表（PANSS）评估症状严重程度。将产科并发症和病史中的创伤性脑损伤作为环境因素进行研究。
未发现C677T多态性与精神分裂症之间存在关联。在PANSS分量表上，基因型对症状严重程度没有影响。未检测到基因型-环境相互作用对精神分裂症症状严重程度的影响。研究结果未证实一些关于C677T多态性与精神分裂症症状关系的研究数据。
