可解除大肠杆菌色氨酸酶合成的分解代谢物阻遏作用的不稳定突变。
Unstable mutations that relieve catabolite repression of tryptophanase synthesis by Escherichia coli.
作者信息
Yudkin M D
出版信息
J Bacteriol. 1977 Apr;130(1):57-61. doi: 10.1128/jb.130.1.57-61.1977.
Abstract
From strains of Escherichia coli that carry deletions of the trp region, five different mutants were isolated that were capable of synthesizing tryptophanase at unusually high rates in conditions of severe catabolite repression. Notwithstanding the comparative insensitivity to catabolite repression, the rates of tryptophanase synthesis in the mutants were greatly diminished by the introduction of a defective gene for adenyl cyclase. Each of the mutants segregated variants of the parental type. The results of genetic analysis appear to be consistent with the mutants arose by duplication of the tryptophanase gene.
摘要
从携带色氨酸区域缺失的大肠杆菌菌株中，分离出了五个不同的突变体，它们能够在严重的分解代谢物阻遏条件下以异常高的速率合成色氨酸酶。尽管对分解代谢物阻遏相对不敏感，但通过引入有缺陷的腺苷酸环化酶基因，突变体中色氨酸酶的合成速率大大降低。每个突变体都分离出了亲本类型的变体。遗传分析结果似乎与这些突变体是由色氨酸酶基因复制产生的这一观点一致。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1966 Jul;56(1):177-84. doi: 10.1073/pnas.56.1.177.
2
Instability of a missense suppressor resulting from a duplication of genetic material.由遗传物质重复导致的错义抑制子的不稳定性。
J Mol Biol. 1969 Feb 14;39(3):563-81. doi: 10.1016/0022-2836(69)90146-6.
3
A mechanism for repressor action.阻遏物作用机制。
J Mol Biol. 1969 Jul 14;43(1):201-13. doi: 10.1016/0022-2836(69)90089-8.
4
Duplication of a gene belonging to an arginine operon of Escherichia coli K-12.大肠杆菌K-12精氨酸操纵子中一个基因的重复。
Genetics. 1968 Oct;60(2):257-68. doi: 10.1093/genetics/60.2.257.
5
Inhibition of lacZ gene translation initiation in trp-lac fusion strains.色氨酸-乳糖操纵子融合菌株中lacZ基因翻译起始的抑制作用。
J Bacteriol. 1974 Mar;117(3):1231-9. doi: 10.1128/jb.117.3.1231-1239.1974.
6
Duplication-translocations of tryptophan operon genes in Escherichia coli.大肠杆菌中色氨酸操纵子基因的重复易位
J Bacteriol. 1973 Oct;116(1):33-40. doi: 10.1128/jb.116.1.33-40.1973.
7
Amino-acid sequence of alpha chains of human haptoglobins.人触珠蛋白α链的氨基酸序列。
Nature. 1968 May 25;218(5143):736-41. doi: 10.1038/218736a0.
8
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9
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J Mol Biol. 1976 Aug 5;105(2):201-18. doi: 10.1016/0022-2836(76)90107-8.
10
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