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大肠杆菌中解除色氨酸酶合成分解代谢物阻遏的突变。远离色氨酸酶基因的突变。

Mutations in Escherichia coli that relieve catabolite repression of tryptophanase synthesis. Mutations distant from the tryptophanase gene.

作者信息

Yudkin M D

出版信息

J Gen Microbiol. 1976 Jan;92(1):125-32. doi: 10.1099/00221287-92-1-125.

DOI:10.1099/00221287-92-1-125
PMID:173793
Abstract

Two mutants are described in which the synthesis of tryptophanase is unusually insensitive to catabolite repression. Neither mutation is linked by transduction to the tryptophane structural gene, neither mutation renders the synthesis of beta-galactosidase insensitive to catabolite repression, and the mutations do not permit tryptophanase to be synthesized in strains deficient in adenyl cyclase. During growth in glucose-minimal medium the mutants maintained a similar intracellular concentration of cyclic AMP to their wild-type parent; but since in the wild type the concentration of cyclic AMP was the same in glycerol-minimal medium as in glucose-minimal medium, it is doubtful whether catabolite repression is mediated by measurable changes in the concentration of this nucleotide.

摘要

本文描述了两个突变体，其中色氨酸酶的合成对分解代谢物阻遏异常不敏感。通过转导，这两个突变均与色氨酸结构基因不连锁，它们均未使β-半乳糖苷酶的合成对分解代谢物阻遏不敏感，并且这些突变不允许在缺乏腺苷酸环化酶的菌株中合成色氨酸酶。在葡萄糖基本培养基中生长期间，这些突变体维持的细胞内环磷酸腺苷（cAMP）浓度与其野生型亲本相似；但由于在野生型中，甘油基本培养基中的cAMP浓度与葡萄糖基本培养基中的相同，因此分解代谢物阻遏是否由该核苷酸浓度的可测量变化介导值得怀疑。

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Mutations in Escherichia coli that relieve catabolite repression of tryptophanase synthesis. Mutations distant from the tryptophanase gene.大肠杆菌中解除色氨酸酶合成分解代谢物阻遏的突变。远离色氨酸酶基因的突变。
J Gen Microbiol. 1976 Jan;92(1):125-32. doi: 10.1099/00221287-92-1-125.
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Transcription initiation at the tryptophanase promoter of Escherichia coli K-12.
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J Bacteriol. 1982 Aug;151(2):942-51. doi: 10.1128/jb.151.2.942-951.1982.
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J Bacteriol. 1981 Sep;147(3):787-96. doi: 10.1128/jb.147.3.787-796.1981.
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