Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
PLoS Genet. 2020 Apr 23;16(4):e1008709. doi: 10.1371/journal.pgen.1008709. eCollection 2020 Apr.
As the maternal-foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to pregnancy. The evolution and functional importance of genomic imprinting are inextricably linked to mammalian placentation. Recent technological advances in mapping and manipulating the epigenome in embryogenesis in mouse models have revealed novel mechanisms regulating genomic imprinting in placental trophoblast, the physiological implications of which are only just beginning to be explored. This review will highlight important recent discoveries and exciting new directions in the study of placental imprinting.
作为母子界面，胎盘对于建立和促进健康妊娠至关重要，它调节胎儿生长和母体对妊娠的适应。基因组印记的进化和功能重要性与哺乳动物胎盘的形成密不可分。近年来，在小鼠模型中绘制和操作胚胎发生中的表观基因组的技术进步揭示了调节胎盘滋养层中基因组印记的新机制，其生理意义才刚刚开始被探索。这篇综述将重点介绍胎盘印记研究中的重要新发现和令人兴奋的新方向。
