Zegveld C, Knape H, Smits J, Belopavlovic M, Caron D, Gallant J, Stockman A, Boghaert A
Anesth Analg. 1978 Nov-Dec;57(6):700-3.
Domperidone was compared with placebo in a multicenter double-blind study of 116 patients (15 to 80 years) with postoperative vomiting. After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection of domperidone 10 mg from an open supply was needed. The period of time until an additional injection was registered and compared between the 2 treatment groups. Fifty-nine percent of the placebo patients needed a 2nd injection before the end of the 6-hour follow-up, compared with only 35% of the domperidone patients (p less than 0.05). When a 2nd injection was required, the time elapsed before it was needed was longer (p = 0.01) in the domperidone group (median 150 minutes) than in the placebo one (median 120 minutes). There were no significant side-effects.
在一项针对116名（年龄在15至80岁之间）术后呕吐患者的多中心双盲研究中，将多潘立酮与安慰剂进行了比较。呕吐发生后，患者静脉注射10毫克多潘立酮或安慰剂。然后对患者进行至少6小时的随访，或者直到需要从开放供应中再次注射10毫克多潘立酮。记录直至再次注射的时间，并在两个治疗组之间进行比较。59%的安慰剂组患者在6小时随访结束前需要再次注射，而多潘立酮组患者仅为35%（p<0.05）。当需要再次注射时，多潘立酮组（中位数150分钟）在需要再次注射之前所经过的时间比安慰剂组（中位数120分钟）更长（p=0.01）。未观察到明显的副作用。
