Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.
Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.
Ecotoxicol Environ Saf. 2020 Jul 1;197:110615. doi: 10.1016/j.ecoenv.2020.110615. Epub 2020 Apr 20.
The respiratory deposition rates are the important analytical parameters for human health risk assessment related to the environmental volatile organic compounds (VOCs). In present study, the deposition rates from the linear regressions of CHO, CHN, CHO, CHO, CHO, CH, CH, CH, and CH of 120 healthy volunteers were obtained with significantly different from the respective calculated deposition rates. The CHO (formaldehyde) has the highest deposition rate, indicating the highest associated exposure risk of CHO if the persons are exposed to the same concentrations of these VOCs through inhalation. In order to explore the effects of the breathing models and sampling time on the deposition rates of VOCs, volunteers were first asked to breathe successively with nasal-in-nasal-out, oral-in-nasal-out, and oral-in-oral-out breathing models before and after three meals for three days. Sampling time variation has no effect on the deposition rates of selected VOCs, while the deposition rates of CHO, CHO, CH, CH and CH by nasal-in-nasal-out were significantly different from oral-in-oral-out and nasal-in-oral-out models. Among all the breathing models, nasal-in-oral-out comprises the entire respiratory system. In order to further validate the results, the deposition rates of the selected VOCs were calculated in 120 healthy volunteers using nasal-in-oral-out breathing model for unlimited time after the conventional lung function examination. Difference in gender and body mass index had no effect on the deposition rates of VOCs, while the age affects the deposition rates of CHO, CHN and CHO. Positive correlation analysis between lung function factors and deposition rates revealed that the individuals with larger lung function factors are more susceptible to deposit the VOCs. Overall, the main conclusion can be drawn that the respiratory deposition rates were influenced by the physiological factors. Therefore, the major objective for future research is to accurately calculate the deposition rates of environmental VOCs for health-risk assessment.
呼吸道沉积率是与环境挥发性有机化合物（VOCs）相关的人体健康风险评估的重要分析参数。在本研究中，通过 120 名健康志愿者的线性回归，获得了 CHO、CHN、CHO、CHO、CHO、CH、CH、CH 和 CH 的沉积率，与各自计算的沉积率有显著差异。CHO（甲醛）具有最高的沉积率，如果这些人通过吸入暴露于相同浓度的这些 VOCs，则表明 CHO 具有最高的相关暴露风险。为了探讨呼吸模型和采样时间对 VOCs 沉积率的影响，志愿者首先被要求连续 3 天在三餐前后分别进行鼻内-鼻出、口内-鼻出和口内-口出呼吸模型呼吸。采样时间变化对所选 VOCs 的沉积率没有影响，而 CHO、CHO、CH、CH 和 CH 通过鼻内-鼻出的沉积率与口内-口出和鼻内-口出模型有显著差异。在所有呼吸模型中，鼻内-口出模型包含整个呼吸系统。为了进一步验证结果，在常规肺功能检查后，使用鼻内-口出呼吸模型计算了 120 名健康志愿者中所选 VOCs 的沉积率，时间不限。性别和体重指数差异对 VOCs 的沉积率没有影响，而年龄影响 CHO、CHN 和 CHO 的沉积率。肺功能因素与沉积率的正相关分析表明，肺功能因素较大的个体更容易沉积 VOCs。总体而言，可以得出主要结论，即呼吸道沉积率受生理因素影响。因此，未来研究的主要目标是准确计算环境 VOCs 的沉积率以进行健康风险评估。
