Department of Chemistry, Umeå University, 90187 Umeå, Sweden.
Department of Chemistry, Umeå University, 90187 Umeå, Sweden.
Sci Total Environ. 2020 Jun 10;720:137444. doi: 10.1016/j.scitotenv.2020.137444. Epub 2020 Feb 20.
Building related health effects or symptoms (BRS), known also as sick-building syndrome (SBS), are a phenomenon that is not well understood. In this study, air samples from 51 rooms associated with BRS and 34 control rooms were collected on multi-sorbent tubes and analyzed by a non-target approach using comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry techniques. The large amount of data gathered was analyzed using multivariate statistics (principle component analysis (PCA) and partial least squares (PLS)). This new analysis approach revealed that in rooms where people experienced BRS, petrochemicals and chemicals emitted from plastics were abundant, whereas in rooms where people did not experience BRS, flavor and fragrance compounds were abundant. Among the petrochemicals benzene and 2-butoxyethanol were found in higher levels in rooms where people experienced BRS. The levels of limonene were sometimes in the range of reported odor thresholds, and similarly 3-carene and beta-myrcene were found in higher concentrations in indoor air of rooms where people did not experience BRS. It cannot be ruled out that these compounds may have influenced the perceived air quality. However, the overall variability in air concentrations was large and it was not possible to accurately predict if the air in a particular room could cause BRS or not.
建筑物相关健康影响或症状（BRS），也称为病态建筑综合征（SBS），是一种尚未被充分理解的现象。在这项研究中，从 51 个与 BRS 相关的房间和 34 个对照房间采集了空气样本，使用多吸附剂管收集，并使用全面二维气相色谱和高分辨率质谱技术采用非靶向方法进行分析。使用多元统计分析（主成分分析（PCA）和偏最小二乘（PLS））对收集到的大量数据进行了分析。这种新的分析方法表明，在人们经历 BRS 的房间中，石油化工品和塑料释放的化学品含量丰富，而在人们没有经历 BRS 的房间中，香料和香精化合物含量丰富。在人们经历 BRS 的房间中，发现了苯和 2-丁氧基乙醇等石油化工品的含量较高。柠檬烯的含量有时处于报道的气味阈值范围内，而类似地，3-蒈烯和β-月桂烯在人们没有经历 BRS 的房间的室内空气中的浓度较高。不能排除这些化合物可能影响了人们对空气质量的感知。然而，空气中浓度的总体变异性很大，无法准确预测特定房间的空气是否会引起 BRS。
