Department of Psychology, Umeå University, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Int J Environ Health Res. 2022 Dec;32(12):2756-2766. doi: 10.1080/09603123.2021.1988908. Epub 2021 Oct 19.
The aim of this study was to investigate if there are differences in symptom ratings and plasma concentrations of oxylipins as a measure of acute inflammation between individuals with building-related symptoms (BRS) and referents during exposure to rooms where people experienced BRS and rooms where they did not experience BRS. Medically examined individuals with BRS and healthy, age and sex matched referents working in the same building were exposed for 60 min. Ratings of symptoms and collection of blood to measure oxylipins in plasma were performed before and after each exposure. Individuals with BRS reported more symptoms (mostly mucosal) than the referents in the problem rooms and there was a tendency towards a difference between the groups in concentration of metabolites from the cyclooxygenase pathway (COX). The mean reported intensity of symptoms among all participants was also found to be positively correlated with both COX and lipoxygenase (LOX-15) oxylipins in problem rooms.
本研究旨在探究在暴露于出现人员相关症状（BRS）的房间和未出现人员相关症状的房间时，具有 BRS 的个体与参照个体之间，症状评分和作为急性炎症指标的氧化脂质（oxylipin）的血浆浓度是否存在差异。将患有 BRS 的经医学检查个体和在同一建筑物中工作的健康、年龄和性别匹配的参照个体暴露于其中 60 分钟。在每次暴露前后，对症状评分和测量血浆中氧化脂质的血液采集进行了评估。与参照个体相比，患有 BRS 的个体在问题房间中报告了更多的症状（主要是粘膜症状），并且两组之间 COX 途径代谢物浓度存在差异的趋势。在所有参与者中，报告的症状强度平均值也与问题房间中的 COX 和脂氧合酶（LOX-15）氧化脂质呈正相关。
