Fujii Yutaka
Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Biology (Basel). 2020 Apr 20;9(4):81. doi: 10.3390/biology9040081.
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient's life by providing an appropriate blood flow and oxygen supply to principal organs. On the other hand, systemic inflammatory responses in patients undergoing cardiovascular surgery supported by CPB contribute significantly to CPB-associated mortality and morbidity. Our previous research showed that CPB causes a systemic inflammatory response and organ damage in a small animal CPB model. We have been studying the effects of hyperoxia and blood plasma substitute on CPB. In this review, we present a study focusing on the systemic inflammatory response during CPB, along with our findings.
体外循环（ECC）方法越来越多地用于对呼吸和心肺循环衰竭的机械支持。特别是在心血管手术期间的心肺转流（CPB），通过向主要器官提供适当的血流和氧气供应来维持患者的生命。另一方面，在CPB支持下进行心血管手术的患者中的全身炎症反应是CPB相关死亡率和发病率的重要因素。我们之前的研究表明，在小动物CPB模型中CPB会引起全身炎症反应和器官损伤。我们一直在研究高氧和血浆代用品对CPB的影响。在这篇综述中，我们介绍了一项关注CPB期间全身炎症反应的研究以及我们的发现。
