Department of Electrical & Computer Engineering, University of Patras, 26504 Patras, Greece.
Industrial Systems Institute, Athena Research Center, 26504 Patras, Greece.
Sensors (Basel). 2020 Apr 21;20(8):2363. doi: 10.3390/s20082363.
Effective management of chronic constrictive pulmonary conditions lies in proper and timely administration of medication. As a series of studies indicates, medication adherence can effectively be monitored by successfully identifying actions performed by patients during inhaler usage. This study focuses on the recognition of inhaler audio events during usage of pressurized metered dose inhalers (pMDI). Aiming at real-time performance, we investigate deep sparse coding techniques including convolutional filter pruning, scalar pruning and vector quantization, for different convolutional neural network (CNN) architectures. The recognition performance has been assessed on three healthy subjects following both within and across subjects modeling strategies. The selected CNN architecture classified drug actuation, inhalation and exhalation events, with 100%, 92.6% and 97.9% accuracy, respectively, when assessed in a leave-one-subject-out cross-validation setting. Moreover, sparse coding of the same architecture with an increasing compression rate from 1 to 7 resulted in only a small decrease in classification accuracy (from 95.7% to 94.5%), obtained by random (subject-agnostic) cross-validation. A more thorough assessment on a larger dataset, including recordings of subjects with multiple respiratory disease manifestations, is still required in order to better evaluate the method's generalization ability and robustness.
慢性紧缩性肺部疾病的有效管理在于正确和及时的药物管理。正如一系列研究表明的那样,通过成功识别患者在使用吸入器时的动作,可以有效地监测药物的依从性。本研究专注于识别使用压力计量吸入器(pMDI)时吸入器的音频事件。为了实现实时性能,我们研究了包括卷积滤波器修剪、标量修剪和矢量量化在内的深度稀疏编码技术,针对不同的卷积神经网络(CNN)架构。在采用基于个体内和跨个体建模策略的三种健康个体上,评估了识别性能。在一个预留一个个体的交叉验证设置中,所选择的 CNN 架构分别以 100%、92.6%和 97.9%的准确度,对药物触发、吸入和呼气事件进行分类。此外,随着压缩率从 1 增加到 7,同一架构的稀疏编码仅导致分类准确度略有下降(从 95.7%下降到 94.5%),这是通过随机(与个体无关)交叉验证获得的。为了更好地评估该方法的泛化能力和鲁棒性,仍需要在更大的数据集上进行更全面的评估,包括对具有多种呼吸疾病表现的个体的记录。