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用于循环性死亡后器官捐献的移动体外膜肺氧合团队

Mobile Extracorporeal Membrane Oxygenation Teams for Organ Donation After Circulatory Death.

作者信息

Figini Maria Adele, Paredes-Zapata David, Juan Eva Oliver, Chiumello Davide Alberto

机构信息

Department of Anesthesia and Intensive Care Unit, ASST Santi Paolo e Carlo, Milano, Italy.

Donation and Transplantation Coordination Unit, Hospital Clinic, Barcelona, Spain.

出版信息

Transplant Proc. 2020 Jun;52(5):1528-1535. doi: 10.1016/j.transproceed.2020.02.045. Epub 2020 Apr 21.

Abstract

The shortage of available organ donors is a significant problem worldwide, and various efforts have been carried out to avoid the loss of potential organ donors. Among them, organ donation from cardiocirculatory deceased donors (DCD), in which withdrawal of life-sustaining therapies is ongoing (Maastricht type III donors), is one emerging strategy. Thanks to the latest advances in transplantation and organ preservation, such as normothermic regional perfusion (NRP), ex vivo perfusion techniques, and good organization and communication among prehospital care providers, emergency departments, intensive care units, and transplantation units, DCD is rapidly increasing; it's estimated that it will increase the number of donations of lungs and splanchnic organs by more than 40%. Although Maastricht type II DCD requires a 24/7 available experienced extra corporeal membrane oxygenation (ECMO) team in the institution, Maastricht DCD type III could be organized in secondary care and spoke hospitals without in loco ECMO facilities for NRP. This article analyses a potential mobile team organization based on the hub-and-spoke model, which already exists and functions in Italy, by estimating the dimension of the controlled DCD phenomenon in Italy, coordination requirements, costs, personnel training, and education, and reporting a single center experience in Milan, Italy.

摘要

可用器官捐赠者的短缺是一个全球性的重大问题,人们已经开展了各种努力来避免潜在器官捐赠者的流失。其中,来自心脏循环死亡捐赠者(DCD)的器官捐赠是一种新兴策略,在这类捐赠中,维持生命的治疗措施正在被撤除(马斯特里赫特III型捐赠者)。由于移植和器官保存方面的最新进展,如常温区域灌注(NRP)、体外灌注技术,以及院前护理人员、急诊科、重症监护病房和移植科室之间良好的组织与沟通,DCD捐赠数量正在迅速增加;据估计,这将使肺和内脏器官的捐赠数量增加40%以上。虽然马斯特里赫特II型DCD需要机构内有一支随时待命的经验丰富的体外膜肺氧合(ECMO)团队,但马斯特里赫特III型DCD可以在二级医疗机构和专科医院组织实施,这些医院无需配备用于NRP的就地ECMO设施。本文通过估计意大利可控DCD现象的规模、协调要求、成本、人员培训和教育情况,并报告意大利米兰一个单一中心的经验,分析了一种基于轴心辐射模式的潜在移动团队组织形式,这种模式在意大利已经存在并发挥作用。

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