Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Department of General Surgery, Affiliated Hospital of Jiangsu University, Jiefang Road No 438, Zhenjiang, Jiangsu, 212002, China.
Cytokine Growth Factor Rev. 2020 Oct;55:48-57. doi: 10.1016/j.cytogfr.2020.03.003. Epub 2020 Apr 12.
Interferon regulatory factors (IRFs) are a family of central transcriptional regulators that produce type I interferon and regulate innate and adaptive immune responses. Interferon regulatory factor 8 (IRF8) exists mainly in hematopoietic cells and is essential for the development of several myeloid lineages, including monocytes/macrophages and dendritic cells. In recent years, an increasing number of studies have focused on the roles of IRF8 in the differentiation of myeloid pedigree and MDSC aggregation in diseases such as tumors. In this review, we provide a comprehensive overview of the roles of IRF8 in the regulation of myeloid cell development, with particular reference to multiple disease conditions. Clarifying the various functions of IRF8 may suggest targets for therapeutic interventions.
干扰素调节因子 (IRFs) 是一类重要的转录调控因子，可产生 I 型干扰素并调节固有和适应性免疫反应。干扰素调节因子 8 (IRF8) 主要存在于造血细胞中，对包括单核细胞/巨噬细胞和树突状细胞在内的几种髓系谱系的发育至关重要。近年来，越来越多的研究关注了 IRF8 在肿瘤等疾病中调节髓系谱系分化和髓系来源抑制细胞 (MDSC) 聚集的作用。在本文中，我们全面概述了 IRF8 在调节髓系细胞发育中的作用，并特别参考了多种疾病状况。阐明 IRF8 的各种功能可能为治疗干预提供靶点。
