Zhu Hongming, Zhu He, Tian Miao, Wang Dongying, He Jiaxing, Xu Tianmin
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Front Genet. 2020 Apr 9;11:347. doi: 10.3389/fgene.2020.00347. eCollection 2020.
Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have demonstrated the importance of DNA methylation and hydroxymethylation in specific genes in the progression of cervical cancer. Determining the methylation and hydroxymethylation profiles of these genes will help in the early prevention and diagnosis, monitoring recurrence, prognosis, and treatment of patients with cervical cancer. In this review, we focus on the significance of aberrant DNA methylation and hydroxymethylation in cervical cancer and the use of these epigenetic signatures in clinical settings.
最近的发现催生了新的理念和技术，有助于阐明表观遗传学与肿瘤生物学之间的关联。如今，肿瘤遗传学领域已发展到涵盖一种新型的表观遗传学调控。越来越多的研究表明，特定基因中的DNA甲基化和羟甲基化在宫颈癌进展中具有重要意义。确定这些基因的甲基化和羟甲基化图谱将有助于宫颈癌患者的早期预防和诊断、复发监测、预后评估及治疗。在本综述中，我们重点关注异常DNA甲基化和羟甲基化在宫颈癌中的意义以及这些表观遗传学特征在临床中的应用。
