Goldstein Amelia, Gersh Mallory, Skovronsky Gabriela, Moss Chailee
Duke University, Durham, NC, USA.
Wake Forest University, Winston-Salem, NC, USA.
Int J Womens Health. 2024 Oct 23;16:1715-1731. doi: 10.2147/IJWH.S474571. eCollection 2024.
Cervical cancer remains a significant health concern, particularly in developing countries, where it is a leading cause of cancer-related deaths among women. Innovative technologies have emerged to improve the efficiency, cost-effectiveness, and sensitivity of cervical cancer screening and treatment methods. This study aims to explore the various approaches for the detection and treatment of human papillomavirus (HPV), cervical dysplasia (CD), and cervical cancer, highlighting new technologies and updated screening strategies in developing areas.
A comprehensive literature search was conducted using PubMed to identify relevant publications on the subject of cervical cancer screening and HPV detection.
HPV infection and cervical cancer continue to pose significant global health challenges. Emerging technologies such as rapid, low-cost HPV testing combined with high-resolution digital colposcopy and artificial intelligence interpretation hold promise for efficient and sensitive screening. Advancements in HPV vaccine distribution, high-risk HPV screening, DNA methylation assays, dual-stain cytology, lab-on-chip assays, and deep learning technologies offer new avenues for improved detection and risk stratification.Research and innovations in detection and treatment methods are crucial for reducing the burden of these diseases worldwide.
Screening for HPV and CD plays a pivotal role in reducing the risk of cervical cancer-related mortality. The development of novel technologies, along with efforts to enhance global health equity and integrate cervical cancer prevention with HIV screening and treatment programs, represent critical steps toward achieving comprehensive cervical cancer screening on a global scale.
宫颈癌仍然是一个重大的健康问题,尤其是在发展中国家,它是女性癌症相关死亡的主要原因。创新技术已经出现,以提高宫颈癌筛查和治疗方法的效率、成本效益和敏感性。本研究旨在探索检测和治疗人乳头瘤病毒(HPV)、宫颈发育异常(CD)和宫颈癌的各种方法,重点介绍发展中地区的新技术和更新的筛查策略。
使用PubMed进行了全面的文献检索,以确定有关宫颈癌筛查和HPV检测主题的相关出版物。
HPV感染和宫颈癌继续对全球健康构成重大挑战。快速、低成本的HPV检测与高分辨率数字阴道镜检查和人工智能解读等新兴技术有望实现高效、灵敏的筛查。HPV疫苗接种、高危HPV筛查、DNA甲基化检测、双染细胞学、芯片实验室检测和深度学习技术的进步为改进检测和风险分层提供了新途径。检测和治疗方法的研究与创新对于减轻全球这些疾病的负担至关重要。
HPV和CD筛查在降低宫颈癌相关死亡率的风险方面起着关键作用。新技术的发展,以及为增强全球健康公平性和将宫颈癌预防与HIV筛查及治疗项目相结合所做的努力,是在全球范围内实现全面宫颈癌筛查的关键步骤。