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严重孕产妇结局女性的孕产妇和围产期死亡率及其预测因素:一项基于坦桑尼亚医疗机构的改善孕产妇和新生儿护理调查。

Incidence and Predictors of Maternal and Perinatal Mortality among Women with Severe Maternal Outcomes: A Tanzanian Facility-Based Survey for Improving Maternal and Newborn Care.

作者信息

Lilungulu Athanase, Bintabara Deogratius, Mujungu Simon, Chiwanga Enid, Chetto Paulo, Nassoro Mzee

机构信息

Department of Obstetrics and Gynaecology, College of Health Sciences, The University of Dodoma, Dodoma, Tanzania.

Department of Public Health, College of Health Sciences, The University of Dodoma, Dodoma, Tanzania.

出版信息

Obstet Gynecol Int. 2020 Apr 10;2020:5390903. doi: 10.1155/2020/5390903. eCollection 2020.

Abstract

INTRODUCTION

Maternal and perinatal mortality is still a major public health challenge in Tanzania, despite the ongoing government efforts to improve maternal and newborn care. Among the contributors to these problems is the high magnitude of severe maternal outcomes (maternal near-miss). The current study, therefore, aimed to identify the magnitude and predictors of maternal and perinatal mortality among women with severe maternal outcomes admitted to Dodoma Regional Referral Hospital.

METHODS

A retrospective cross-sectional study was conducted from October 2015 to January 2016 at Dodoma Regional Referral Hospital in Dodoma City. All maternal deaths and maternal near-misses based on WHO criteria were included in this study. Three outcome variables have been identified: maternal mortality, perinatal mortality, and neonatal complications. To examine the predictors for the three predetermined outcome variables, the three logit models each containing unadjusted and adjusted findings were fitted. A -value less than 0.05 was considered indicative of statistically significant.

RESULTS

A total of 3600 pregnant women were admitted for obstetric reasons during the mentioned period. 140 of them were diagnosed with severe maternal outcomes; hence, they were included in this study. The severe maternal outcome incidence ratio was 40.23 per 1000 live births, the institutional maternal mortality ratio was 459.77 per 100000 live births, and the perinatal mortality rate was 10.83 per 1000 total births. Most of the maternal morbidity and mortality were due to direct causes in which postpartum hemorrhage and hypertensive disorders were the leading causes. In adjusted analysis, per-protocol management, maternal age, and mode of birth were predictors of maternal mortality, perinatal mortality, and neonatal complications, respectively.

CONCLUSION

Establishing and strengthening obstetric ICUs will help reduce maternal mortality as the response time from the onset of obstetric complications, while the provision of high-quality care will be substantially reduced. Furthermore, the study recommends regular provision of in-service refresher training to emphasize the practice and compliance of per-protocol case management through a team approach in order to reduce the burden of maternal and perinatal mortality in Tanzania.

摘要

引言

尽管坦桑尼亚政府一直在努力改善孕产妇和新生儿护理,但孕产妇和围产期死亡率仍是该国面临的一项重大公共卫生挑战。这些问题的成因之一是严重孕产妇结局(孕产妇接近死亡)的发生率很高。因此,本研究旨在确定多多马地区转诊医院收治的有严重孕产妇结局的妇女中孕产妇和围产期死亡率的规模及预测因素。

方法

2015年10月至2016年1月在多多马市的多多马地区转诊医院进行了一项回顾性横断面研究。本研究纳入了所有符合世界卫生组织标准的孕产妇死亡和孕产妇接近死亡病例。确定了三个结局变量:孕产妇死亡率、围产期死亡率和新生儿并发症。为了检验这三个预定结局变量的预测因素,分别拟合了三个逻辑回归模型,每个模型都包含未调整和调整后的结果。P值小于0.05被认为具有统计学意义。

结果

在上述期间,共有3600名孕妇因产科原因入院。其中140人被诊断为有严重孕产妇结局,因此被纳入本研究。严重孕产妇结局发生率为每1000例活产40.23例,机构孕产妇死亡率为每100000例活产459.77例,围产期死亡率为每1000例总出生10.83例。大多数孕产妇发病和死亡是由直接原因导致的,其中产后出血和高血压疾病是主要原因。在调整分析中,按方案管理、孕产妇年龄和分娩方式分别是孕产妇死亡率、围产期死亡率和新生儿并发症的预测因素。

结论

建立和加强产科重症监护病房将有助于降低孕产妇死亡率,因为从产科并发症发作开始的反应时间将大幅缩短,同时高质量护理的提供也将得到改善。此外,该研究建议定期提供在职进修培训,以强调通过团队方法进行按方案病例管理的实践和依从性,从而减轻坦桑尼亚孕产妇和围产期死亡的负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f086/7171678/9e19bb6cf7d4/OGI2020-5390903.001.jpg

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