Sarathy Vinu, Jayappa Sriniivas Belagutty, Waran Thianesh, Naik Radheshyam
Department of Medical Oncology, HealthCare Global Enterprises Ltd., Bangalore, India.
Case Rep Oncol Med. 2020 Apr 9;2020:9268923. doi: 10.1155/2020/9268923. eCollection 2020.
Asymptomatic minimal pericardial effusion may be frequently found in patients with hypothyroidism. Cardiac tamponade secondary to hypothyroidism is rarely referenced in medical literature. Hypothyroidism as an adverse effect of pazopanib (tyrosine kinase inhibitor) treatment leading to cardiac tamponade is an even rarer occurrence. Here, we report an unusual case of a 71-year-old male, with a case of renal cell carcinoma on pazopanib treatment presenting with shortness of breath who was found to have hypothyroidism with a large pericardial effusion leading to cardiac tamponade. The patient did not have any prior reports of thyroid-stimulating hormone (TSH) or thyroid hormone levels at presentation. No such case of cardiac tamponade due to hypothyroidism as an adverse effect of pazopanib tablet treatment has been reported to our knowledge.
无症状的微量心包积液在甲状腺功能减退患者中可能经常被发现。医学文献中很少提及甲状腺功能减退继发的心包填塞。帕唑帕尼（一种酪氨酸激酶抑制剂）治疗导致心包填塞的甲状腺功能减退作为不良反应则更为罕见。在此，我们报告一例不寻常的病例，一名71岁男性，正在接受帕唑帕尼治疗肾细胞癌，出现呼吸急促，被发现患有甲状腺功能减退并伴有大量心包积液导致心包填塞。患者就诊时没有任何先前的促甲状腺激素（TSH）或甲状腺激素水平报告。据我们所知，尚无因帕唑帕尼片剂治疗不良反应导致甲状腺功能减退引起心包填塞的此类病例报告。
