• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用于细胞追踪中数据关联的深度强化学习

Deep Reinforcement Learning for Data Association in Cell Tracking.

作者信息

Wang Junjie, Su Xiaohong, Zhao Lingling, Zhang Jun

机构信息

School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.

Department of Rehabilitation, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, China.

出版信息

Front Bioeng Biotechnol. 2020 Apr 9;8:298. doi: 10.3389/fbioe.2020.00298. eCollection 2020.

DOI:10.3389/fbioe.2020.00298
PMID:32328484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7161216/
Abstract

Accurate target detection and association are vital for the development of reliable target tracking, especially for cell tracking based on microscopy images due to the similarity of cells. We propose a deep reinforcement learning method to associate the detected targets between frames. According to the dynamic model of each target, the cost matrix is produced by conjointly considering various features of targets and then used as the input of a neural network. The proposed neural network is trained using reinforcement learning to predict a distribution over the association solution. Furthermore, we design a residual convolutional neural network that results in more efficient learning. We validate our method on two applications: the multiple target tracking simulation and the ISBI cell tracking. The results demonstrate that our approach based on reinforcement learning techniques could effectively track targets following different motion patterns and show competitive results.

摘要

准确的目标检测与关联对于可靠的目标跟踪发展至关重要,特别是对于基于显微镜图像的细胞跟踪,因为细胞之间具有相似性。我们提出一种深度强化学习方法来关联帧间检测到的目标。根据每个目标的动态模型,通过联合考虑目标的各种特征来生成代价矩阵,然后将其用作神经网络的输入。所提出的神经网络使用强化学习进行训练,以预测关联解决方案上的分布。此外,我们设计了一种残差卷积神经网络,可实现更高效的学习。我们在两个应用中验证了我们的方法:多目标跟踪模拟和ISBI细胞跟踪。结果表明,我们基于强化学习技术的方法能够有效地跟踪遵循不同运动模式的目标,并显示出具有竞争力的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/76a8910e539b/fbioe-08-00298-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/e89da809929f/fbioe-08-00298-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/efcdc6ba6880/fbioe-08-00298-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/76a8910e539b/fbioe-08-00298-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/e89da809929f/fbioe-08-00298-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/efcdc6ba6880/fbioe-08-00298-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77cf/7161216/76a8910e539b/fbioe-08-00298-g0003.jpg

相似文献

1
Deep Reinforcement Learning for Data Association in Cell Tracking.用于细胞追踪中数据关联的深度强化学习
Front Bioeng Biotechnol. 2020 Apr 9;8:298. doi: 10.3389/fbioe.2020.00298. eCollection 2020.
2
A deep learning framework for automatic detection of arbitrarily shaped fiducial markers in intrafraction fluoroscopic images.一种用于在分次透视图像中自动检测任意形状基准标记的深度学习框架。
Med Phys. 2019 May;46(5):2286-2297. doi: 10.1002/mp.13519. Epub 2019 Apr 15.
3
Relation3DMOT: Exploiting Deep Affinity for 3D Multi-Object Tracking from View Aggregation.Relation3DMOT:基于视图聚合的深度关联的 3D 多目标跟踪。
Sensors (Basel). 2021 Mar 17;21(6):2113. doi: 10.3390/s21062113.
4
Deep Reinforcement Learning-Based End-to-End Control for UAV Dynamic Target Tracking.基于深度强化学习的无人机动态目标跟踪端到端控制
Biomimetics (Basel). 2022 Nov 11;7(4):197. doi: 10.3390/biomimetics7040197.
5
Action-Driven Visual Object Tracking With Deep Reinforcement Learning.基于深度强化学习的驱动式视觉目标跟踪
IEEE Trans Neural Netw Learn Syst. 2018 Jun;29(6):2239-2252. doi: 10.1109/TNNLS.2018.2801826.
6
Searching and Tracking an Unknown Number of Targets: A Learning-Based Method Enhanced with Maps Merging.搜索和跟踪未知数量的目标:一种基于学习并通过地图合并增强的方法。
Sensors (Basel). 2021 Feb 4;21(4):1076. doi: 10.3390/s21041076.
7
Energy Conservation for Internet of Things Tracking Applications Using Deep Reinforcement Learning.基于深度强化学习的物联网跟踪应用中的节能
Sensors (Basel). 2021 May 8;21(9):3261. doi: 10.3390/s21093261.
8
: Image-Specific Inference for 3D Segmentation.用于3D分割的特定图像推理
Front Neurorobot. 2020 Jul 24;14:49. doi: 10.3389/fnbot.2020.00049. eCollection 2020.
9
Deep-learning method for data association in particle tracking.基于深度学习的数据关联在粒子追踪中的方法。
Bioinformatics. 2020 Dec 8;36(19):4935-4941. doi: 10.1093/bioinformatics/btaa597.
10
Attention-aware fully convolutional neural network with convolutional long short-term memory network for ultrasound-based motion tracking.基于注意力感知的全卷积神经网络与卷积长短期记忆网络的超声运动跟踪
Med Phys. 2019 May;46(5):2275-2285. doi: 10.1002/mp.13510. Epub 2019 Apr 22.

引用本文的文献

1
Cell-TRACTR: A transformer-based model for end-to-end segmentation and tracking of cells.Cell-TRACTR:一种基于Transformer的细胞端到端分割与跟踪模型。
PLoS Comput Biol. 2025 May 23;21(5):e1013071. doi: 10.1371/journal.pcbi.1013071. eCollection 2025 May.
2
DeepKymoTracker: A tool for accurate construction of cell lineage trees for highly motile cells.深度运动轨迹追踪器:一种用于为高迁移性细胞精确构建细胞谱系树的工具。
PLoS One. 2025 Feb 10;20(2):e0315947. doi: 10.1371/journal.pone.0315947. eCollection 2025.
3
A Weakly Supervised Learning Method for Cell Detection and Tracking Using Incomplete Initial Annotations.

本文引用的文献

1
ECFS-DEA: an ensemble classifier-based feature selection for differential expression analysis on expression profiles.ECFS-DEA:基于集成分类器的特征选择方法,用于表达谱上的差异表达分析。
BMC Bioinformatics. 2020 Feb 5;21(1):43. doi: 10.1186/s12859-020-3388-y.
2
psSubpathway: a software package for flexible identification of phenotype-specific subpathways in cancer progression.psSubpathway:一个软件包,用于灵活识别癌症进展中表型特异性亚途径。
Bioinformatics. 2020 Apr 1;36(7):2303-2305. doi: 10.1093/bioinformatics/btz894.
3
Computational and Biological Methods for Gene Therapy.
基于不完全初始标注的细胞检测和跟踪弱监督学习方法。
Int J Mol Sci. 2023 Nov 7;24(22):16028. doi: 10.3390/ijms242216028.
4
Multi-Target Coordinated Search Algorithm for Swarm Robotics Considering Practical Constraints.考虑实际约束的群体机器人多目标协同搜索算法
Front Neurorobot. 2021 Dec 6;15:753052. doi: 10.3389/fnbot.2021.753052. eCollection 2021.
5
Quantitative Approaches to Study Retinal Neurogenesis.研究视网膜神经发生的定量方法。
Biomedicines. 2021 Sep 14;9(9):1222. doi: 10.3390/biomedicines9091222.
6
Next-Generation Digital Histopathology of the Tumor Microenvironment.肿瘤微环境的下一代数字病理切片。
Genes (Basel). 2021 Apr 7;12(4):538. doi: 10.3390/genes12040538.
7
Automated Tracking of Cortical Oligodendrocytes.皮质少突胶质细胞的自动追踪
Front Cell Neurosci. 2021 Apr 12;15:667595. doi: 10.3389/fncel.2021.667595. eCollection 2021.
8
Reinforcement Learning-Based Data Association for Multiple Target Tracking in Clutter.基于强化学习的数据关联在杂波中的多目标跟踪。
Sensors (Basel). 2020 Nov 18;20(22):6595. doi: 10.3390/s20226595.
9
A bird's-eye view of deep learning in bioimage analysis.生物图像分析中深度学习的鸟瞰图。
Comput Struct Biotechnol J. 2020 Aug 7;18:2312-2325. doi: 10.1016/j.csbj.2020.08.003. eCollection 2020.
基因治疗的计算与生物学方法
Curr Gene Ther. 2019;19(4):210. doi: 10.2174/156652321904191022113307.
4
Computational Methods for Identifying Similar Diseases.识别相似疾病的计算方法
Mol Ther Nucleic Acids. 2019 Dec 6;18:590-604. doi: 10.1016/j.omtn.2019.09.019. Epub 2019 Sep 28.
5
gutMDisorder: a comprehensive database for dysbiosis of the gut microbiota in disorders and interventions.gutMDisorder:一个综合数据库,用于研究疾病和干预措施中肠道微生物失调。
Nucleic Acids Res. 2020 Jan 8;48(D1):D554-D560. doi: 10.1093/nar/gkz843.
6
Identifying emerging phenomenon in long temporal phenotyping experiments.识别长时程表型实验中的新兴现象。
Bioinformatics. 2020 Jan 15;36(2):568-577. doi: 10.1093/bioinformatics/btz559.
7
Combining gene ontology with deep neural networks to enhance the clustering of single cell RNA-Seq data.将基因本体论与深度神经网络相结合,以增强单细胞 RNA-Seq 数据的聚类。
BMC Bioinformatics. 2019 Jun 10;20(Suppl 8):284. doi: 10.1186/s12859-019-2769-6.
8
A learning-based framework for miRNA-disease association identification using neural networks.基于神经网络的 miRNA-疾病关联识别学习框架。
Bioinformatics. 2019 Nov 1;35(21):4364-4371. doi: 10.1093/bioinformatics/btz254.
9
Mining Relationships among Multiple Entities in Biological Networks.生物网络中多个实体间的关系挖掘。
IEEE/ACM Trans Comput Biol Bioinform. 2020 May-Jun;17(3):769-776. doi: 10.1109/TCBB.2019.2904965. Epub 2019 Mar 13.
10
Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method.基于数据整合方法的阿尔茨海默病相关基因鉴定
Front Genet. 2019 Jan 25;9:703. doi: 10.3389/fgene.2018.00703. eCollection 2018.