gutMDisorder：一个综合数据库，用于研究疾病和干预措施中肠道微生物失调。
gutMDisorder: a comprehensive database for dysbiosis of the gut microbiota in disorders and interventions.
机构信息
NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin, Heilongjiang, China, 150028.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China, 150081.
出版信息
Nucleic Acids Res. 2020 Jan 8;48(D1):D554-D560. doi: 10.1093/nar/gkz843.
gutMDisorder (http://bio-annotation.cn/gutMDisorder), a manually curated database, aims at providing a comprehensive resource of dysbiosis of the gut microbiota in disorders and interventions. Alterations in the composition of the gut microbial community play crucial roles in the development of chronic disorders. And the beneficial effects of drugs, foods and other intervention measures on disorders could be microbially mediated. The current version of gutMDisorder documents 2263 curated associations between 579 gut microbes and 123 disorders or 77 intervention measures in Human, and 930 curated associations between 273 gut microbes and 33 disorders or 151 intervention measures in Mouse. Each entry in the gutMDisorder contains detailed information on an association, including an intestinal microbe, a disorder name, intervention measures, experimental technology and platform, characteristic of samples, web sites for downloading the sequencing data, a brief description of the association, a literature reference, and so on. gutMDisorder provides a user-friendly interface to browse, retrieve each entry using gut microbes, disorders, and intervention measures. It also offers pages for downloading all the entries and submitting new experimentally validated associations.
肠道微生物失调数据库 (http://bio-annotation.cn/gutMDisorder)，是一个人工 curated 的数据库，旨在提供一个关于失调的肠道微生物群在疾病和干预中的综合资源。肠道微生物群落组成的改变在慢性疾病的发展中起着至关重要的作用。药物、食物和其他干预措施对疾病的有益影响可能是微生物介导的。肠道微生物失调数据库的当前版本记录了 2263 个在人类中 579 种肠道微生物和 123 种疾病或 77 种干预措施之间的 curated 关联，以及在小鼠中 273 种肠道微生物和 33 种疾病或 151 种干预措施之间的 930 个 curated 关联。肠道微生物失调数据库中的每个条目都包含关于关联的详细信息，包括肠道微生物、疾病名称、干预措施、实验技术和平台、样本特征、用于下载测序数据的网站、关联的简要说明、文献参考等。肠道微生物失调数据库提供了一个用户友好的界面来浏览、检索使用肠道微生物、疾病和干预措施的每个条目。它还提供了下载所有条目的页面，并提供了提交新的经过实验验证的关联的页面。
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