The Norwegian Continence and Pelvic Floor Center, University Hospital of North Norway, P.O. Box 96, 9038, Tromsø, Norway.
Department of Obstetrics and Gynecology, Helsingborg Hospital, Lund's University, Helsingborg, Sweden.
Arch Gynecol Obstet. 2020 Jun;301(6):1479-1484. doi: 10.1007/s00404-020-05550-1. Epub 2020 Apr 23.
The present study aimed to assess the risk of obstetric anal sphincter injuries (OASIS) of a subsequent delivery after the previous OASIS in countries with low (Finland) and high rates (Norway and Sweden) of OASIS.
This population-based case-control study included women who experienced OASIS 1997-2002. 26,598 women with OASIS were included from countries with low (Finland) and high (Norway and Sweden) OASIS incidences. Each case was matched with one background-adjusted control without OASIS. A follow-up data, including all subsequent deliveries between 1998 and 2011 were then collected. Statistics significances were calculated using chi-square test, test for relative proportions and Students t test, where appropriate.
OASIS in the first birth was associated with increased recurrences in subsequent births, 6.9% vs. 1.7% in Norway (p < 0.001); 4.5% vs. 0.7 (p < 0.001) in Sweden; and 2.1% vs. 0.8% in Finland (p = 0.038). In Norway, more than two deliveries occurred in 4.8% of cases and 6.2% of controls (p = 0.001), 4.2% vs. 5.1% in Sweden (p < 0.001), and 5.7% vs. 6.3% in Finland (p = 0.572). For women with OASIS in a previous delivery, the rates of cesarean deliveries in subsequent pregnancies were 16.4% (7.9% for controls) in Norway, and 16.3% (6.0% for controls) in Sweden, and 50.2% (14.2% for controls) in Finland. In all countries, the differences between cases and controls were significant (p < 0.001).
Next deliveries after OASIS are associated with increased frequency of new OASIS, more cesarean deliveries, and less subsequent deliveries in the high-risk population than women without previous OASIS.
本研究旨在评估在产科肛门括约肌损伤(OASIS)发生率较低的国家(芬兰)和较高的国家(挪威和瑞典)中,前次 OASIS 后再次分娩发生 OASIS 的风险。
本基于人群的病例对照研究纳入了 1997 年至 2002 年期间发生 OASIS 的女性。从 OASIS 发生率较低的国家(芬兰)和较高的国家(挪威和瑞典)中纳入了 26598 名 OASIS 患者。每个病例均与一名无 OASIS 的背景调整对照相匹配。然后收集了 1998 年至 2011 年期间所有后续分娩的随访数据。使用卡方检验、相对比例检验和学生 t 检验(适当情况下)计算统计学显著性。
首次分娩中的 OASIS 与随后分娩中复发的风险增加相关,在挪威为 6.9%对 1.7%(p<0.001);在瑞典为 4.5%对 0.7%(p<0.001);在芬兰为 2.1%对 0.8%(p=0.038)。在挪威,4.8%的病例和 6.2%的对照者发生了两次以上分娩(p=0.001),在瑞典为 4.2%对 5.1%(p<0.001),在芬兰为 5.7%对 6.3%(p=0.572)。对于前次分娩中有 OASIS 的女性,随后妊娠中的剖宫产率在挪威为 16.4%(对照组为 7.9%),在瑞典为 16.3%(对照组为 6.0%),在芬兰为 50.2%(对照组为 14.2%)。在所有国家,病例与对照者之间的差异均具有统计学意义(p<0.001)。
在前次 OASIS 后再次分娩与新 OASIS 的发生频率增加、更多的剖宫产分娩以及高危人群中随后分娩的次数减少相关,而与无前次 OASIS 的女性相比。