Casado Flores J, García Pérez J, Valdivielso A, Monleón M
Departamento de Pediatría de la Facultad de Medicina, Hospital Niño Jesús, Universidad Autónoma de Madrid.
An Esp Pediatr. 1988 Nov;29(5):374-6.
Meningococcal sepsis is a frequent disease in our population with a bad prognosis even in a few hours. The search for easy and fast to obtain criteria of severity is essential decrease in order to the mortality rates. We have studied in 56 patients ranged from two months to six years, with bacteriological confirmation of meningococcal sepsis, the clinical and analytical parameters at admission, in order to find those parameters with a better correlation with the severity of the process. Global mortality was 25%. Eleven out of 21 children (52%) with less than 2,000 neutrophils in peripheral blood at the time of admission died, while only three died in the 35 resting group (p less than 0.01). When it was associated with a small age, less than two years, mortality raised up to 60%. In our series, the prognosis based upon the total neutrophils at admission, can be compared with that obtained from the five parameters of severity from Sthiem-Samrosch, that take an hour to be obtained. Absolute neutrophil count and age, can be obtained at the time of admission assessing the severity of the disease in short time.
脑膜炎球菌败血症在我国人群中是一种常见疾病，即使在数小时内预后也很差。寻找简便快速的严重程度标准对于降低死亡率至关重要。我们研究了56例年龄从两个月到六岁、经细菌学确诊为脑膜炎球菌败血症的患者，分析了入院时的临床和分析参数，以找出与病情严重程度相关性更好的参数。总体死亡率为25%。入院时外周血中性粒细胞少于2000的21名儿童中有11名（52%）死亡，而其余35名儿童中只有3名死亡（p<0.01）。当与低龄（小于两岁）相关时，死亡率高达60%。在我们的系列研究中，基于入院时总中性粒细胞数的预后，可与从施蒂姆-萨姆罗施的五个严重程度参数得出的预后相比较，获取这五个参数需要一个小时。入院时即可获得绝对中性粒细胞计数和年龄，能在短时间内评估疾病的严重程度。
