Department of Morphology and Pathology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Department of Molecular and Cellular Radiobiology, Seversk Biophysical Research Center, Federal Medical-Biological Agency of Russia, Seversk, Russia.
Bull Exp Biol Med. 2020 Apr;168(6):785-788. doi: 10.1007/s10517-020-04802-z. Epub 2020 Apr 23.
Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.
纳米级磁铁颗粒（磁性纳米球）是新型诊断和治疗制剂的有前景的基础。在成年大鼠中，研究了单次静脉注射壳聚糖修饰的纳米级磁铁颗粒后 120 天内的血液白细胞结构和白细胞公式。未检测到壳聚糖修饰的磁性纳米球对大鼠血液白细胞结构的影响。注射壳聚糖修饰的磁性纳米球悬浮液与单核细胞、分叶和杆状嗜中性粒细胞水平升高以及大鼠血液中淋巴细胞计数减少有关。白细胞计数参数的变化是暂时的，注射后第 40 天恢复正常。
