基于纳米磁铁矿的静脉注射磁脂体后大鼠血白细胞。

Rat Blood Leukocytes after Intravenous Injection of Magnetoliposomes on the Basis of Nanomagnetite.

机构信息

Department of Morphology and General Pathology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

Department of Molecular and Cellular Radiology, Seversk Biophysical Research Center, Federal Medical-Biological Agency, Seversk, Russia.

出版信息

Bull Exp Biol Med. 2021 Oct;171(6):774-777. doi: 10.1007/s10517-021-05314-0. Epub 2021 Oct 27.

DOI:10.1007/s10517-021-05314-0

PMID:34705182

Abstract

The structure of blood neutrophils, eosinophils, monocytes, and lymphocytes and differential white blood count in adult rats were studied over 120 days after a single intravenous injection of magnetoliposomes based on nanomagnetite. Magnetoliposomes had no effect on the structure of neutrophils, eosinophils, monocytes, and lymphocytes. At the same time, injection of a suspension of magnetoliposomes based on magnetite nanoparticles led to a decrease in lymphocyte count and an increase in the count of monocytes and band and segmented neutrophils in the blood. These changes were transient and the parameters returned to normal by day 40-60 after injection.

摘要

研究了纳米磁铁矿为基础的脂质体单次静脉注射后 120 天内成年大鼠血液中性粒细胞、嗜酸性粒细胞、单核细胞和淋巴细胞的结构和白细胞分类计数。脂质体对中性粒细胞、嗜酸性粒细胞、单核细胞和淋巴细胞的结构没有影响。同时，注射基于磁铁矿纳米粒子的脂质体悬液会导致淋巴细胞计数减少，单核细胞计数增加，血液中的带状和分节状中性粒细胞增多。这些变化是短暂的，注射后 40-60 天内参数恢复正常。