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机器人手术在虚弱老年人中的应用:围手术期结局分析。

Robotic Surgery in the Frail Elderly: Analysis of Perioperative Outcomes.

机构信息

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

European Institute of Oncology, Milan, Italy.

出版信息

Ann Surg Oncol. 2020 Oct;27(10):3772-3780. doi: 10.1245/s10434-020-08475-w. Epub 2020 Apr 23.

Abstract

PURPOSE

The frail are considered at higher risk for unfavorable surgical outcomes (major complications/mortality). We assessed the safety of and outcomes associated with robotic surgery in the frail elderly undergoing gynecologic procedures.

METHODS

We identified patients aged ≥ 65 years who underwent a robotic procedure between May 2007 and December 2016. Frailty was defined as the presence of at least three of five frailty factors-more than five comorbidities, low physical activity, weight loss, exhaustion, and fatigue. Perioperative outcomes were recorded. We compared variables among frail and non-frail patients and performed a multivariate logistic regression to detect variables associated with major complications (≥ grade 3) or 90-day mortality.

RESULTS

We identified 982 patients: 71 frail and 911 non-frail patients. Median age was 71 years. Median BMI was 29.8 kg/m. Thirty-four patients (3.5%) had a 30-day readmission. Seventy-seven (7.8%) had a postoperative complication, of which 23 (2.3%) were major. Ninety-day mortality was 0.5%. There were significant differences with regard to age (P < 0.001), body mass index (BMI) (P < 0.001) and performance status (P < 0.001); the frail were more likely to have had surgery for oncologic reasons (P = 0.047). There were differences in hospital stay (P < 0.001), postoperative (P = 0.042) and major complications (P = 0.007), and 90-day mortality (P = 0.05). At multivariable logistic regression, age ≥ 85 was associated with major complications. BMI, performance status, and major complications were associated with 90-day mortality.

CONCLUSIONS

The frail elderly have longer hospital stays and more complications after surgery than the general population, consistent with the reported literature. Careful selection of surgical candidates is required.

摘要

目的

身体虚弱的人被认为有更高的手术不良结局(主要并发症/死亡率)风险。我们评估了在接受妇科手术的体弱老年人中进行机器人手术的安全性和相关结果。

方法

我们确定了 2007 年 5 月至 2016 年 12 月期间接受机器人手术的年龄≥65 岁的患者。虚弱的定义是存在至少五个虚弱因素中的三个以上-超过五种合并症、低体力活动、体重减轻、疲惫和乏力。记录围手术期结果。我们比较了虚弱患者和非虚弱患者之间的变量,并进行了多变量逻辑回归分析,以检测与主要并发症(≥3 级)或 90 天死亡率相关的变量。

结果

我们确定了 982 名患者:71 名虚弱患者和 911 名非虚弱患者。中位年龄为 71 岁。中位 BMI 为 29.8kg/m。34 名患者(3.5%)在 30 天内再次入院。77 名(7.8%)患者发生术后并发症,其中 23 名(2.3%)为主要并发症。90 天死亡率为 0.5%。年龄(P<0.001)、体重指数(BMI)(P<0.001)和表现状态(P<0.001)方面存在显著差异;虚弱患者更有可能因肿瘤原因接受手术(P=0.047)。住院时间(P<0.001)、术后(P=0.042)和主要并发症(P=0.007)以及 90 天死亡率(P=0.05)存在差异。多变量逻辑回归分析显示,年龄≥85 岁与主要并发症相关。BMI、表现状态和主要并发症与 90 天死亡率相关。

结论

与报告的文献一致,体弱老年人手术后住院时间较长,并发症较多。需要仔细选择手术候选人。

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