Division of Urology, University of São Paulo School of Medicine, São Paulo, Brazil.
Department of Urology, Moinhos de Vento Hospital, Porto Alegre, Brazil.
Curr Med Res Opin. 2020 Aug;36(8):1403-1415. doi: 10.1080/03007995.2020.1760806. Epub 2020 May 14.
To evaluate the effect of individual lower urinary tract symptoms (LUTS) and LUTS-specific bother on daily/leisure activities, work productivity and treatment behaviors and satisfaction in a Brazilian population reporting symptoms of the overactive bladder (OAB) syndrome. Secondary analysis of Brazil LUTS study data, including individuals ≥40 years old with a possible diagnosis of OAB, based on a score of ≥8 on the OAB-V8 questionnaire. Participants used a 5-point Likert scale to rate occurrence of LUTS during the previous month. Regression models were constructed to analyze association of symptom frequency and bother, controlled for demographics, comorbid conditions, habits and body mass index, to outcomes related to people's lives and treatment patterns. This analysis included 5184 individuals (53% female), 24.4% of whom received a possible diagnosis of OAB. There was a greater likelihood of OAB symptoms in men reporting depression/anxiety (2.0 times), diabetes (1.8 times), or constipation (1.9 times) and women reporting depression/anxiety (2.6 times), constipation (1.7 times), and being overweight (1.4 times) or obese (1.8 times). Symptoms of all categories, including voiding, storage, and post-micturition, were associated with a negative impact on individuals' lives, quality of life and treatment-related outcomes. Treatment seeking for OAB was low among men and women overall (35.1 and 43.6%, respectively), with highest rates among individuals in the 60-69 age group. LUTS of all categories impacted all domains studied. These results highlight the importance of comprehensive LUTS assessment in OAB patients, including voiding, storage and post-micturition symptoms.
为了评估个体下尿路症状（LUTS）及其对日常生活/休闲活动、工作生产力以及治疗行为和满意度的影响，我们对巴西有膀胱过度活动症（OAB）症状的人群进行了下尿路症状研究数据的二次分析，包括年龄≥40 岁、OAB-V8 问卷评分≥8 的可能 OAB 患者。参与者使用 5 分制 Likert 量表评估上个月 LUTS 的发生频率。构建回归模型分析症状频率和困扰与与人们生活和治疗模式相关的结局的相关性，控制了人口统计学、合并症、习惯和体重指数。该分析包括 5184 名患者（53%为女性），其中 24.4%可能被诊断为 OAB。有抑郁/焦虑（2.0 倍）、糖尿病（1.8 倍）或便秘（1.9 倍）的男性和有抑郁/焦虑（2.6 倍）、便秘（1.7 倍）、超重（1.4 倍）或肥胖（1.8 倍）的女性报告 OAB 症状的可能性更大。所有类别的症状，包括排尿、储存和排尿后，均与个体生活、生活质量和治疗相关结局的负面影响相关。总体而言，男性和女性对 OAB 的治疗需求均较低（分别为 35.1%和 43.6%），60-69 岁年龄组的需求最高。所有类别的 LUTS 均对所有研究领域产生影响。这些结果突出了对 OAB 患者进行全面 LUTS 评估的重要性，包括排尿、储存和排尿后症状。
