New insights into the synthesis, toxicity and applications of gold nanoparticles in CT imaging and treatment of cancer.

The past decades have witnessed enormous development of gold nanoparticles (AuNPs) and their applications in the biomedical field, an area in which they show infinite potential. Abundant investigations have been conducted in improving AuNP synthesis, aimed at obtaining water-dispersible ultrasmall AuNPs, which can exhibit biocompatibility, renal clearance and minimal toxicity. Due to their excellent x-ray attenuation ability, special optical properties and surface modification properties, AuNPs are reported to be promising as computed tomography contrast agents and can be applied in radiotherapy, photothermal and photodynamic therapies, and drug delivery. In this review, synthesis methods and toxicity of AuNPs have been summarized, emphasizing the preparation of ultra-small AuNPs. Applications of AuNPs in computed tomography imaging and cancer treatment are also considered, revealing their potential in the clinic.