Beik Jaber, Khademi Sara, Attaran Neda, Sarkar Saeed, Shakeri-Zadeh Ali, Ghaznavi Habib, Ghadiri Hossein
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.
Curr Med Chem. 2017;24(39):4399-4416. doi: 10.2174/0929867324666170810154917.
Gold nanoparticles (AuNPs), owing to their elegant physicochemical properties, have recently been introduced as promising theranostic nanoparticles. Folic acid is a necessary vitamin for cell proliferation. Accordingly, the surface functionalization of AuNP with folic acid may offer a great potential for the development of a strategy to increase the efficiency of cancer diagnosis and therapy based on the new nanotechnology. In this study, we have reviewed the recent progress made in the design and the biomedical application of various folate-conjugated gold nanoparticles (FAuNPs).
We performed a structured search in bibliographic databases and made a comprehensive list of relevant papers. The main subjects considered in this review included (1) methods for the preparation of F-AuNPs, (2) applications of F-AuNPs in computed tomography (CT), and (3) the use of F-AuNPs in targeted cancer therapy.
As many as 96 papers were selected for the review. Accordingly, we explained the noncovalent and the covalent methods of fabricating the various types of F-AuNPs. Particular applications of F-AuNP in cancer diagnosis using the CT scan modality were described. In addition, the applications of F-AuNPs in targeted radiation therapy, chemotherapy, and hyperthermia were elucidated in depth. In the hyperthermia section, we presented certain extra explanations on F-AuNP-based laser, radiofrequency, and ultrasoundbased hyperthermia methods.
This review identifies the important roles of F-AuNPs in current cancer studies that are being undertaken worldwide. The findings of this review confirm that F-AuNP is a new theranostic agent, which has a great potential for simultaneous cancer therapy and diagnosis.
金纳米颗粒（AuNPs）因其出色的物理化学性质，最近被引入作为有前景的治疗诊断纳米颗粒。叶酸是细胞增殖所必需的维生素。因此，用叶酸对金纳米颗粒进行表面功能化可能为基于新纳米技术提高癌症诊断和治疗效率的策略开发提供巨大潜力。在本研究中，我们综述了各种叶酸共轭金纳米颗粒（FAuNPs）在设计和生物医学应用方面的最新进展。
我们在文献数据库中进行了结构化搜索，并列出了相关论文的综合清单。本综述考虑的主要主题包括：（1）FAuNPs的制备方法；（2）FAuNPs在计算机断层扫描（CT）中的应用；（3）FAuNPs在靶向癌症治疗中的应用。
共选择了96篇论文进行综述。因此，我们解释了制备各种类型FAuNPs的非共价和共价方法。描述了FAuNP在使用CT扫描模式进行癌症诊断中的具体应用。此外，还深入阐明了FAuNPs在靶向放射治疗、化疗和热疗中的应用。在热疗部分，我们对基于FAuNP的激光、射频和超声热疗方法进行了一些额外的解释。
本综述确定了FAuNPs在全球范围内正在进行的当前癌症研究中的重要作用。本综述的结果证实，FAuNP是一种新的治疗诊断剂，在癌症治疗和诊断方面具有巨大潜力。
